Breitinger U, Sticht H, Breitinger HG (2021)
Publication Type: Journal article
Publication year: 2021
The inhibitory glycine receptor (GlyR) is a principal mediator of fast synaptic inhibition in mammalian spinal cord, brainstem, and higher brain centres. Flavonoids are secondary plant metabolites that exhibit many beneficial physiological effects, including modulatory action on neuronal receptors. Using whole-cell current recordings from recombinant human α1 GlyRs, expressed in HEK293 cells, we compared the flavonols kaempferol and quercetin, the flavanone naringenin, the flavones apigenin and nobiletin, the isoflavone genistein, and two gingerols, 6-gingerol and 8-gingerol for their modulation of receptor currents. All compounds were inhibitors of the GlyR with IC
APA:
Breitinger, U., Sticht, H., & Breitinger, H.G. (2021). Modulation of recombinant human alpha 1 glycine receptor by flavonoids and gingerols. Biological Chemistry. https://dx.doi.org/10.1515/hsz-2020-0360
MLA:
Breitinger, Ulrike, Heinrich Sticht, and Hans Georg Breitinger. "Modulation of recombinant human alpha 1 glycine receptor by flavonoids and gingerols." Biological Chemistry (2021).
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