Neoadjuvant chemoradiation combined with regional hyperthermia in locally advanced or recurrent rectal cancer

Ott O, Gani C, Lindner LH, Schmidt M, Lamprecht U, Abdel-Rahman S, Hinke A, Weissmann T, Hartmann A, Issels RD, Zips D, Belka C, Grützmann R, Fietkau R (2021)

Publication Type: Journal article

Publication year: 2021

Journal

Cancers MDPI

Book Volume: 13

Pages Range: 1-13

Article Number: 1279

Journal Issue: 6

DOI: 10.3390/cancers13061279

Abstract

Background: To prospectively analyze feasibility and pathological complete response (pCR) rates of neoadjuvant chemoradiotherapy combined with regional hyperthermia (RHT) in patients with locally advanced (LARC) or recurrent (LRRC) rectal cancer. Methods: between 2012 and 2018, 111 patients with UICC stage IIB-IV or any locally recurrent rectal cancer were included (HyRec-Trial, ClinicalTrials.gov Identifier: NCT01716949). Patients received radiotherapy with concurrent 5-Fluororuracil (5-FU)/Capecitabine and Oxaliplatin, and RHT. Stage 1 feasibility analysis evaluated dose-limiting toxicities (DLT) after 19 patients, stage 2 after 59 evaluable patients. Analysis of the pCR rate was based on histopathological reports. Results: the feasibility rates for stages 1 and 2 were 90% (17/19) and 73% (43/59), respectively. In the intention-to-treat population the pCR rate was 19% (20/105; 90% confidence interval (CI) 13.0–26.5). In the per-protocol-analysis, complete tumor regression was seen in 28% (18/64) and 38% (3/8) of the patients with LARC and LRRC, respectively. Complete resection rates (R0) among patients with LARC and LRRC who received surgery were 99% (78/84) and 67% (8/12). Conclusions: the intensified neoadjuvant and multimodality treatment schedule was feasible and led to comparable early toxicity rates as described by other trials that used the similar chemoradiation protocol. The presented treatment regimen resulted in a very high pCR rate and appears as a promising option for patients with LRRC.

Authors with CRIS profile

Oliver Ott Medizinische Fakultät Arndt Hartmann Lehrstuhl für Allgemeine Pathologie und Pathologische Anatomie Robert Grützmann Department of Surgery Rainer Fietkau Lehrstuhl für Strahlentherapie

Involved external institutions

Klinikum der Universität München DE Germany (DE) Universitätsklinikum Tübingen DE Germany (DE)

How to cite

APA:

Ott, O., Gani, C., Lindner, L.H., Schmidt, M., Lamprecht, U., Abdel-Rahman, S.,... Fietkau, R. (2021). Neoadjuvant chemoradiation combined with regional hyperthermia in locally advanced or recurrent rectal cancer. Cancers, 13(6), 1-13. https://dx.doi.org/10.3390/cancers13061279

MLA:

Ott, Oliver, et al. "Neoadjuvant chemoradiation combined with regional hyperthermia in locally advanced or recurrent rectal cancer." Cancers 13.6 (2021): 1-13.

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