Sustainable preparation of anti-inflammatory atorvastatin PLGA nanoparticles

Grune C, Zens C, Czapka A, Scheuer K, Thamm J, Hoeppener S, Jandt KD, Werz O, Neugebauer U, Fischer D (2021)

Publication Type: Journal article

Publication year: 2021

Journal

International Journal of Pharmaceutics Elsevier

Book Volume: 599

Article Number: 120404

DOI: 10.1016/j.ijpharm.2021.120404

Abstract

In the present study, the anti-inflammatory lipophilic drug atorvastatin was encapsulated in poly(D,L-lactide-co-glycolide) (PLGA) using a sustainable method in comparison to the standard emulsion-diffusion-evaporation technique. For the sustainable method the organic solvent ethyl acetate was fully replaced by 400 g/mol poly(ethylene glycol) (PEG 400). Both techniques led to the formation of nanoparticles with comparable sizes of about 170 to 247 nm depending on the polymer type, with monomodal size distribution and negative zeta potential. All nanoparticles demonstrated a high biocompatibility in a shell-less hen's egg model and displayed an anti-inflammatory effect in human monocytes. The use of PEG 400 resulted in plasticizing effects and a lower crystallinity of the PLGA nanoparticles as determined by differential scanning calorimetry and Raman spectroscopy, which correlated with a faster drug release. Interestingly, the particles prepared by the sustainable method showed a crystallinity and drug release kinetics similar to nanoparticles made of PEG-PLGA using the standard method. Conclusively, the sustainable method is a fast and easy to perform technique suitable to prepare atorvastatin-loaded PLGA nanoparticles avoiding toxic and environmentally damaging drawbacks frequently associated with classical organic solvents.

Authors with CRIS profile

Dagmar Fischer Lehrstuhl für Pharmazeutische Technologie und Biopharmazie

Involved external institutions

Leibniz-Institut für Photonische Technologien e.V. DE Germany (DE) Friedrich-Schiller-Universität Jena DE Germany (DE)

How to cite

APA:

Grune, C., Zens, C., Czapka, A., Scheuer, K., Thamm, J., Hoeppener, S.,... Fischer, D. (2021). Sustainable preparation of anti-inflammatory atorvastatin PLGA nanoparticles. International Journal of Pharmaceutics, 599. https://dx.doi.org/10.1016/j.ijpharm.2021.120404

MLA:

Grune, Christian, et al. "Sustainable preparation of anti-inflammatory atorvastatin PLGA nanoparticles." International Journal of Pharmaceutics 599 (2021).

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