The traveling heads 2.0: Multicenter reproducibility of quantitative imaging methods at 7 Tesla

Voelker MN, Kraff O, Goerke S, Laun FB, Hanspach J, Pine KJ, Ehses P, Zaiß M, Liebert A, Straub S, Eckstein K, Robinson S, Nagel AM, Stefanescu MR, Wollrab A, Klix S, Felder J, Hock M, Bosch D, Weiskopf N, Speck O, Ladd ME, Quick HH (2021)

Publication Type: Journal article

Publication year: 2021

Journal

Book Volume: 232

Article Number: 117910

DOI: 10.1016/j.neuroimage.2021.117910

Abstract

Object: This study evaluates inter-site and intra-site reproducibility at ten different 7 T sites for quantitative brain imaging. Material and Methods: Two subjects – termed the “traveling heads” – were imaged at ten different 7 T sites with a harmonized quantitative brain MR imaging protocol. In conjunction with the system calibration, MP2RAGE, QSM, CEST and multi-parametric mapping/relaxometry were examined. Results: Quantitative measurements with MP2RAGE showed very high reproducibility across sites and subjects, and errors were in concordance with previous results and other field strengths. QSM had high inter-site reproducibility for relevant subcortical volumes. CEST imaging revealed systematic differences between the sites, but reproducibility was comparable to results in the literature. Relaxometry had also very high agreement between sites, but due to the high sensitivity, differences caused by different applications of the B1 calibration of the two RF coil types used were observed. Conclusion: Our results show that quantitative brain imaging can be performed with high reproducibility at 7 T and with similar reliability as found at 3 T for multicenter studies of the supratentorial brain.

Authors with CRIS profile

Involved external institutions

Universitätsklinikum Würzburg Germany (DE) Universität Duisburg-Essen (UDE) Germany (DE) Max-Planck-Institut für Kognitions- und Neurowissenschaften / Max Planck Institute for Human Cognitive and Brain Sciences Germany (DE) Deutsches Krebsforschungszentrum (DKFZ) Germany (DE) Otto-von-Guericke-Universität Magdeburg Germany (DE) Medizinische Universität Wien Austria (AT) Max-Delbrück-Centrum für Molekulare Medizin / Max Delbrück Center for Molecular Medicine (MDC) Berlin-Buch Germany (DE) Max-Planck-Institut für biologische Kybernetik / Max Planck Institute for Biological Cybernetics Germany (DE) Forschungszentrum Jülich / Research Centre Jülich (FZJ) Germany (DE) Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE) Germany (DE)

How to cite

APA:

Voelker, M.N., Kraff, O., Goerke, S., Laun, F.B., Hanspach, J., Pine, K.J.,... Quick, H.H. (2021). The traveling heads 2.0: Multicenter reproducibility of quantitative imaging methods at 7 Tesla. NeuroImage, 232. https://dx.doi.org/10.1016/j.neuroimage.2021.117910

MLA:

Voelker, Maximilian N., et al. "The traveling heads 2.0: Multicenter reproducibility of quantitative imaging methods at 7 Tesla." NeuroImage 232 (2021).

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