Crossing the barriers: Revisiting the gut feeling in rheumatoid arthritis
Brandl C, Bucci L, Schett G, Zaiss M (2021)
Publication Type: Journal article, Review article
Publication year: 2021
Journal
Abstract
To avoid autoimmunity, it is essential to keep the balance between the defence against pathogens and the maintenance of tolerance to self-antigens. Mucosal inflammation may lead to breakdown of tolerance and activation of autoreactive cells. Growing evidence suggests a major contribution of gut microbiota to the onset of chronic, autoimmune inflammatory diseases including rheumatoid arthritis (RA). RA patients show significant differences in the composition of gut microbiota compared to healthy controls, and in murine arthritis models certain bacteria can induce inflammatory Th17 responses or autoantibody production. The gut microbiota plays an important role in regulating the balance between immunogenic and tolerogenic immune responses. The intestinal barrier is the site of the body where most host–microbiota interaction takes place. Certain microbiota or their metabolites can cause a break in homeostasis by affecting the intestinal barrier integrity and permeability. However, an intact intestinal barrier is essential to separate the intestinal epithelium from toxins, microorganisms, and antigens in the gut lumen. This review will focus on the correlation between a leaky gut and the onset of arthritis. Furthermore, it will be discussed how targeting the intestinal barrier function by dietary changes might provide an opportunity to modulate the development of RA.
Authors with CRIS profile
Carolin Brandl
Department of Medicine 3 – Rheumatology and Immunology
Georg Schett
Lehrstuhl für Innere Medizin III
Mario Zaiss
Department of Medicine 3 – Rheumatology and Immunology
Involved external institutions
Italy (IT)How to cite
APA:
Brandl, C., Bucci, L., Schett, G., & Zaiss, M. (2021). Crossing the barriers: Revisiting the gut feeling in rheumatoid arthritis. European Journal of Immunology. https://dx.doi.org/10.1002/eji.202048876
MLA:
Brandl, Carolin, et al. "Crossing the barriers: Revisiting the gut feeling in rheumatoid arthritis." European Journal of Immunology (2021).
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