A CD22-Shp1 phosphatase axis controls integrin beta(7) display and B cell function in mucosal immunity
Ballet R, Brennan M, Brandl C, Feng N, Berri J, Cheng J, Ocon B, Alborzian Deh Sheikh A, Marki A, Bi Y, Abram CL, Lowell CA, Tsubata T, Greenberg HB, Macauley MS, Ley K, Nitschke L, Butcher EC (2021)
Publication Type: Journal article
Publication year: 2021
Journal
DOI: 10.1038/s41590-021-00862-z
Abstract
Lymphocyte homing to the gut and Peyer's patches requires expression of integrin alpha(4)beta(7). Ballet and colleagues report that B cell expression of CD22 is required to specifically retain surface expression of beta(7) integrin molecules, thereby promoting B cell retention in the gut and optimal gut mucosal antibody responses.
Authors with CRIS profile
Involved external institutions
VA Palo Alto Health Care System
United States (USA) (US)
Tokyo Medical and Dental University (TMDU) / 東京医科歯科大学
Japan (JP)
La Jolla Institute for Immunology
United States (USA) (US)
University of Alberta
Canada (CA)
University of California San Francisco (UCSF)
United States (USA) (US)
United States (USA) (US)
Tokyo Medical and Dental University (TMDU) / 東京医科歯科大学
Japan (JP)
La Jolla Institute for Immunology
United States (USA) (US)
University of Alberta
Canada (CA)
University of California San Francisco (UCSF)
United States (USA) (US)
How to cite
APA:
Ballet, R., Brennan, M., Brandl, C., Feng, N., Berri, J., Cheng, J.,... Butcher, E.C. (2021). A CD22-Shp1 phosphatase axis controls integrin beta(7) display and B cell function in mucosal immunity. Nature Immunology. https://doi.org/10.1038/s41590-021-00862-z
MLA:
Ballet, Romain, et al. "A CD22-Shp1 phosphatase axis controls integrin beta(7) display and B cell function in mucosal immunity." Nature Immunology (2021).
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