Ion-doped Brushite Cements for Bone Regeneration
Hurle K, Oliveira JM, Reis RL, Pina S, Götz-Neunhoeffer F (2021)
Publication Type: Journal article, Review article
Publication year: 2021
Journal
DOI: 10.1016/j.actbio.2021.01.004
Abstract
Decades of research in orthopaedics has culminated in the quest for formidable yet resorbable biomaterials using bioactive materials. Brushite cements most salient features embrace high biocompatibility, bioresorbability, osteoconductivity, self-setting characteristics, handling, and injectability properties. Such type of materials is also effectively applied as drug delivery systems. However, brushite cements possess limited mechanical strength and fast setting times. By means of incorporating bioactive ions, which are incredibly promising in directing cell fate when incorporated within biomaterials, it can yield biomaterials with superior mechanical properties. Therefore, it is a key to develop fine-tuned regenerative medicine therapeutics. A comprehensive overview of the current accomplishments of ion-doped brushite cements for bone tissue repair and regeneration is provided herein. The role of ionic substitution on the cements physicochemical properties, such as structural, setting time, hydration products, injectability, mechanical behaviour and ion release is discussed. Cell-material interactions, osteogenesis, angiogenesis, and antibacterial activity of the ion-doped cements, as well as its potential use as drug delivery carriers are also presented.
Authors with CRIS profile
Related research project(s)
Involved external institutions
Portugal (PT)How to cite
APA:
Hurle, K., Oliveira, J.M., Reis, R.L., Pina, S., & Götz-Neunhoeffer, F. (2021). Ion-doped Brushite Cements for Bone Regeneration. Acta Biomaterialia. https://dx.doi.org/10.1016/j.actbio.2021.01.004
MLA:
Hurle, Katrin, et al. "Ion-doped Brushite Cements for Bone Regeneration." Acta Biomaterialia (2021).
BibTeX: Download