2-Fluoro-5-nitrophenyldiazonium: A Novel Sanger-Type Reagent for the Versatile Functionalization of Alcohols

Fischer O, Heinrich M (2021)

Publication Type: Journal article

Publication year: 2021

Journal

Chemistry - A European Journal Wiley

DOI: 10.1002/chem.202100187

Abstract

As a novel Sanger-type reagent, 2-fluoro-5-nitrophenyldiazonium tetrafluoroborate enabled the versatile functionalization of primary and secondary aliphatic alcohols. Based on a mild nucleophilic aromatic substitution of the fluorine atom under unprecedented, base-free conditions, the diazonium unit on the aromatic core of the resulting aryl-alkyl ether could be employed for such diverse transformations as radical C−H activation and cyclization, as well as palladium catalyzed cross-coupling reactions.

Authors with CRIS profile

Oliver Fischer Professur für Pharmazeutische Chemie Markus Heinrich Professur für Pharmazeutische Chemie

How to cite

APA:

Fischer, O., & Heinrich, M. (2021). 2-Fluoro-5-nitrophenyldiazonium: A Novel Sanger-Type Reagent for the Versatile Functionalization of Alcohols. Chemistry - A European Journal. https://dx.doi.org/10.1002/chem.202100187

MLA:

Fischer, Oliver, and Markus Heinrich. "2-Fluoro-5-nitrophenyldiazonium: A Novel Sanger-Type Reagent for the Versatile Functionalization of Alcohols." Chemistry - A European Journal (2021).

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