Hiß S, Eckstein M, Segschneider P, Mantsopoulos K, Iro H, Hartmann A, Agaimy A, Haller F, Mueller SK (2021)
Publication Type: Journal article
Publication year: 2021
Book Volume: 13
Pages Range: 1-14
Article Number: 965
Journal Issue: 5
Objectives: The aim of this study was to assess the number of tumour‐infiltrating lympho-cytes (TILs) and the expression of Programmed Cell Death 1 Ligand 1 (PD‐L1) in Acinic Cell Carcinoma (AciCC) of the salivary glands, to enable a correlation with clinico‐pathological features and to analyse their prognostic impact. Methods: This single centre retrospective study represents a cohort of 36 primary AciCCs with long‐term clinical follow‐up. Immunohistochemically defined immune cell subtypes, i.e., those expressing T‐cell markers (CD3, CD4 and CD8) or a B‐cell marker (CD20) were characterized on tumour tissue sections. The number of TILs was quantitatively evaluated using software for digital bioimage analysis (QuPath). PD‐L1 expression on the tumour cells and on immune cells was assessed immunohistochemically employing established scoring criteria: tu-mour proportion score (TPS), Ventana immune cell score (IC‐Score) and combined positive score (CPS). Results: Higher numbers of tumour‐infiltrating T‐ and B‐ lymphocytes were significantly associated with high‐grade transformation. Furthermore, higher counts of T‐lymphocytes correlated with node‐positive disease. There was a significant correlation between higher levels of PD‐ L1 expression and lymph node metastases as well as the occurrence of high‐grade transformation. Moreover, PD‐L1 CPS was associated with poor prognosis regarding metastasis‐free survival (p = 0.049). Conclusions: The current study is the first to demonstrate an association between PD‐L1 expression and lymph node metastases as well as grading in AciCCs. In conclusion, increased immune cell infiltration of T and B cells as well as higher levels of PD‐L1 expression in AciCC in association with high‐grade transformation, lymph node metastasis and unfavourable prognosis suggests a rel-evant interaction between tumour cells and immune cell infiltrates in a subset of AciCCs, and might represent a rationale for immune checkpoint inhibition.
APA:
Hiß, S., Eckstein, M., Segschneider, P., Mantsopoulos, K., Iro, H., Hartmann, A.,... Mueller, S.K. (2021). Tumour‐infiltrating lymphocytes (Tils) and pd‐l1 expression correlate with lymph node metastasis, high‐grade transformation and shorter metastasis‐free survival in patients with acinic cell carcinoma (acicc) of the salivary glands. Cancers, 13(5), 1-14. https://dx.doi.org/10.3390/cancers13050965
MLA:
Hiß, Selina, et al. "Tumour‐infiltrating lymphocytes (Tils) and pd‐l1 expression correlate with lymph node metastasis, high‐grade transformation and shorter metastasis‐free survival in patients with acinic cell carcinoma (acicc) of the salivary glands." Cancers 13.5 (2021): 1-14.
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