Adipogenic, chondrogenic, osteogenic, and antimicrobial features of glass ceramic material supplemented with manganese

Rau JV, De Stefanis A, Barbaro K, Fosca M, Yankova VG, Matassa R, Nottola SA, Nawaz Q, Ali MS, Peukert W, Boccaccini AR (2021)

Publication Type: Journal article

Publication year: 2021

Journal

Book Volume: 559

Article Number: 120709

DOI: 10.1016/j.jnoncrysol.2021.120709

Abstract

Innovative Mn-containing glass ceramic (Na2O[2.00]-K2O[0.09]-MgO[3.10]-MnO[2.07]-CaO[38.78]-CaF2[2.25]-P2O5[9.66]-SiO2[41.71] [wt%]) was obtained by sol-gel. It was investigated by High Resolution Field Emission Scanning Electron Microscopy, Energy Dispersive X-Ray Spectroscopy, X-Ray fluorescence, X-Ray Diffraction, and Fourier Transform Infrared Spectroscopy. Ion release characteristics of the glass ceramic powder were quantified via Inductively Coupled Plasma Optical Emission Spectroscopy. Biological tests were performed using equine adipose tissue mesenchymal stem cells (AMSCs). MTT assay demonstrated the cytocompatibility of the prepared material. AMSCs differentiation test showed that the glass ceramic favored the stem cell differentiation in adipogenic, chondrogenic, and osteogenic lineages, the last one being qualitatively more pronounced. The antimicrobial properties were evaluated against Escherichia coli, Enterococcus faecalis, Pseudomonas aeruginosa, Salmonella typhi, and Staphylococcus aureus bacteria strains and Candida albicans fungus. The inhibition of Gram-negative bacteria (S. tiphy, E. coli), Gram-positive (E. faecalis) and fungus (C. albicans) was detected, while the inhibition of P. aeruginosa and S. aureus was not significant.

Authors with CRIS profile

Involved external institutions

Istituto di struttura della materia (ISM) Italy (IT) Istituto Zooprofilattico Sperimentale delle Regioni Lazio e Toscana (IZSLT) Italy (IT) I.M. Sechenov First Moscow State Medical University Russian Federation (RU) Università degli studi "La Sapienza" Italy (IT)

How to cite

APA:

Rau, J.V., De Stefanis, A., Barbaro, K., Fosca, M., Yankova, V.G., Matassa, R.,... Boccaccini, A.R. (2021). Adipogenic, chondrogenic, osteogenic, and antimicrobial features of glass ceramic material supplemented with manganese. Journal of Non-Crystalline Solids, 559. https://dx.doi.org/10.1016/j.jnoncrysol.2021.120709

MLA:

Rau, Julietta V., et al. "Adipogenic, chondrogenic, osteogenic, and antimicrobial features of glass ceramic material supplemented with manganese." Journal of Non-Crystalline Solids 559 (2021).

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