Convergence of 3D printed biomimetic wound dressings and adult stem cell therapy.
Shafiee A, Cavalcanti A, Saidy NT, Schneidereit D, Friedrich O, Ravichandran A, De-Juan-Pardo EM, Hutmacher DW (2021)
Publication Status: Published
Publication Type: Journal article, Original article
Publication year: 2021
Journal
Book Volume: 268
Pages Range: 120558
DOI: 10.1016/j.biomaterials.2020.120558
Abstract
Biomimetically designed medical-grade polycaprolactone (mPCL) dressings are 3D-printed with pore architecture and anisotropic mechanical characteristics that favor skin wound healing with reduced scarring. Melt electrowritten mPCL dressings are seeded with human gingival tissue multipotent mesenchymal stem/stromal cells and cryopreserved using a clinically approved method. The regenerative potential of fresh or frozen cell-seeded mPCL dressing is compared in a splinted full-thickness excisional wound in a rat model over six weeks. The application of 3D-printed mPCL dressings decreased wound contracture and significantly improved skin regeneration through granulation and re-epithelialization compared to control groups. Combining 3D-printed biomimetic wound dressings and precursor cell delivery enhances physiological wound closure with reduced scar tissue formation.
Authors with CRIS profile
Dominik Schneidereit
Sonderforschungsbereich/Transregio 225/2: Von den Grundlagen der Biofabrikation zu funktionalen Gewebemodellen
Oliver Friedrich
Lehrstuhl für Medizinische Biotechnologie (MBT)
Involved external institutions
Australia (AU)How to cite
APA:
Shafiee, A., Cavalcanti, A., Saidy, N.T., Schneidereit, D., Friedrich, O., Ravichandran, A.,... Hutmacher, D.W. (2021). Convergence of 3D printed biomimetic wound dressings and adult stem cell therapy. Biomaterials, 268, 120558. https://doi.org/10.1016/j.biomaterials.2020.120558
MLA:
Shafiee, Abbas, et al. "Convergence of 3D printed biomimetic wound dressings and adult stem cell therapy." Biomaterials 268 (2021): 120558.
BibTeX: Download