Convergence of 3D printed biomimetic wound dressings and adult stem cell therapy.

Shafiee A, Cavalcanti A, Saidy NT, Schneidereit D, Friedrich O, Ravichandran A, De-Juan-Pardo EM, Hutmacher DW (2021)


Publication Status: Published

Publication Type: Journal article, Original article

Publication year: 2021

Journal

Book Volume: 268

Pages Range: 120558

DOI: 10.1016/j.biomaterials.2020.120558

Abstract

Biomimetically designed medical-grade polycaprolactone (mPCL) dressings are 3D-printed with pore architecture and anisotropic mechanical characteristics that favor skin wound healing with reduced scarring. Melt electrowritten mPCL dressings are seeded with human gingival tissue multipotent mesenchymal stem/stromal cells and cryopreserved using a clinically approved method. The regenerative potential of fresh or frozen cell-seeded mPCL dressing is compared in a splinted full-thickness excisional wound in a rat model over six weeks. The application of 3D-printed mPCL dressings decreased wound contracture and significantly improved skin regeneration through granulation and re-epithelialization compared to control groups. Combining 3D-printed biomimetic wound dressings and precursor cell delivery enhances physiological wound closure with reduced scar tissue formation.

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How to cite

APA:

Shafiee, A., Cavalcanti, A., Saidy, N.T., Schneidereit, D., Friedrich, O., Ravichandran, A.,... Hutmacher, D.W. (2021). Convergence of 3D printed biomimetic wound dressings and adult stem cell therapy. Biomaterials, 268, 120558. https://doi.org/10.1016/j.biomaterials.2020.120558

MLA:

Shafiee, Abbas, et al. "Convergence of 3D printed biomimetic wound dressings and adult stem cell therapy." Biomaterials 268 (2021): 120558.

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