Effects of 16 months of high intensity resistance training on thigh muscle fat infiltration in elderly men with osteosarcopenia
Ghasemikaram M, Chaudry O, Nagel AM, Uder M, Jakob F, Kemmler W, Kohl M, Engelke K (2021)
Publication Type: Journal article
Publication year: 2021
Journal
DOI: 10.1007/s11357-020-00316-8
Abstract
Osteosarcopenia is characterized by a progressive decline in muscle function and bone strength and associated with muscle fat accumulation. This study aimed to determine the effect of long-term high intensity resistance training (HIRT) on thigh muscle fat infiltration in older men with osteosarcopenia. Forty-three community-dwelling men (72 years and older) were randomly assigned to either an exercise group (EG, n = 21) or an inactive control group (CG, n = 22). EG participants performed a supervised single-set exercise training with high effort two times per week. Participants of both groups were individually provided with dietary protein to reach a cumulative intake of 1.5-1.6 g/kg/day or 1.2-1.3 g/kg/day (EG/CG), respectively, and Up to 10,000 IE/week of Vitamin-D were supplemented in participants with 25 OH Vitamin-D 3 levels below 100 nmol/l. Magnetic resonance (MR) imaging was performed to determine muscle and adipose tissue volume and fat fraction of the thigh. At baseline, there were no significant differences between the two groups. After 16 month,, there were significant training effects of 15% (p = 0.004) on intermuscular adipose tissue (IMAT) volume, which increased in the CG (p = 0.012) and was stable in the EG. In parallel, fat fraction within the deep fascia of the thigh (Baseline, EG: 18.2 vs CG: 15.5, p = 0.16) significantly differed between the groups (Changes, EG: 0.77% vs. CG: 7.7%, p = 0.009). The study confirms the role of fat infiltration of the muscles as an advanced imaging marker in osteosarcopenia and the favorable effects of HIRT on adipose tissue volume of the thigh, in men with osteosarcopenia.
Authors with CRIS profile
Mansour Ghasemikaram
Lehrstuhl für Medizinische Physik und Mikrogewebetechnik
Oliver Chaudry
Medizinische Fakultät
Armin Michael Nagel
Professur für metabolische und funktionelle MR-Bildgebung
Michael Uder
Lehrstuhl für Diagnostische Radiologie
Wolfgang Kemmler
Lehrstuhl für Medizinische Physik und Mikrogewebetechnik
Klaus Engelke
Medizinische Fakultät
Involved external institutions
Germany (DE)How to cite
APA:
Ghasemikaram, M., Chaudry, O., Nagel, A.M., Uder, M., Jakob, F., Kemmler, W.,... Engelke, K. (2021). Effects of 16 months of high intensity resistance training on thigh muscle fat infiltration in elderly men with osteosarcopenia. GeroScience. https://dx.doi.org/10.1007/s11357-020-00316-8
MLA:
Ghasemikaram, Mansour, et al. "Effects of 16 months of high intensity resistance training on thigh muscle fat infiltration in elderly men with osteosarcopenia." GeroScience (2021).
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