Voltage-Switchable Biosensor with Gold Nanoparticles on TiO2Nanotubes Decorated with CdS Quantum Dots for the Detection of Cholesterol and H2O2

Khaliq N, Rasheed MA, Khan M, Maqbool M, Ahmad M, Karim S, Nisar A, Schmuki P, Cho SO, Ali G (2021)

Publication Type: Journal article

Publication year: 2021

Journal

ACS Applied Materials and Interfaces American Chemical Society

DOI: 10.1021/acsami.0c19979

Abstract

A thin layer of gold nanoparticles (Au NPs) sputtered on cadmium sulfide quantum dots (CdS QDs) decorated anodic titanium dioxide nanotubes (TNTs) (Au/CdS QDs/TNTs) was fabricated and explored for the nonenzymatic detection of cholesterol and hydrogen peroxide (H2O2). Morphological studies of the sensor revealed the formation of uniform nanotubes decorated with a homogeneously dispersed CdS QDs and Au NPs layer. The electrochemical measurements showed an enhanced electrocatalytic performance with a fast electron transfer (∼2 s) between the redox centers of each analyte and electrode surface. The hybrid nanostructure (Au/CdS QDs/TNTs) electrode exhibited about a 6-fold increase in sensitivity for both cholesterol (10,790 μA mM-1 cm-2) and H2O2 (78,833 μA mM-1 cm-2) in analyses compared to the pristine samples. The hybrid electrode utilized different operational potentials for both analytes, which may lead to a voltage-switchable dual-analyte biosensor with a higher selectivity. The biosensor also demonstrated a good reproducibility, thermal stability, and increased shelf life. In addition, the clinical significance of the biosensor was tested for cholesterol and H2O2 in real blood samples, which showed maximum relative standard deviations of 1.8 and 2.3%, respectively. These results indicate that a Au/CdS QDs/TNTs-based hybrid nanostructure is a promising choice for an enzyme-free biosensor due to its suitable band gap alignment and higher electrocatalytic activities.

Authors with CRIS profile

Patrik Schmuki Lehrstuhl für Werkstoffwissenschaften (Korrosion und Oberflächentechnik)

Involved external institutions

Pakistan Institute of Nuclear Science and Technology PK Pakistan (PK) Pakistan Institute of Engineering & Applied Sciences (PIEAS) PK Pakistan (PK) Korea Advanced Institute of Science and Technology (KAIST) KR Korea, Republic of (KR)

How to cite

APA:

Khaliq, N., Rasheed, M.A., Khan, M., Maqbool, M., Ahmad, M., Karim, S.,... Ali, G. (2021). Voltage-Switchable Biosensor with Gold Nanoparticles on TiO2Nanotubes Decorated with CdS Quantum Dots for the Detection of Cholesterol and H2O2. ACS Applied Materials and Interfaces. https://dx.doi.org/10.1021/acsami.0c19979

MLA:

Khaliq, Nilem, et al. "Voltage-Switchable Biosensor with Gold Nanoparticles on TiO2Nanotubes Decorated with CdS Quantum Dots for the Detection of Cholesterol and H2O2." ACS Applied Materials and Interfaces (2021).

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