Characterization of gait variability in multiple system atrophy and Parkinson's disease
Sidoroff V, Raccagni C, Kaindlstorfer C, Eschlboeck S, Fanciulli A, Granata R, Eskofier B, Seppi K, Poewe W, Willeit J, Kiechl S, Mahlknecht P, Stockner H, Marini K, Schorr O, Rungger G, Klucken J, Wenning G, Gaßner H (2020)
Publication Type: Journal article
Publication year: 2020
Journal
DOI: 10.1007/s00415-020-10355-y
Abstract
Background Gait impairment is a pivotal feature of parkinsonian syndromes and increased gait variability is associated with postural instability and a higher risk of falls. Objectives We compared gait variability at different walking velocities between and within groups of patients with Parkinson-variant multiple system atrophy, idiopathic Parkinson's disease, and a control group of older adults. Methods Gait metrics were recorded in 11 multiple system atrophy, 12 Parkinson's disease patients, and 18 controls using sensor-based gait analysis. Gait variability was analyzed for stride, swing and stance time, stride length and gait velocity. Values were compared between and within the groups at self-paced comfortable, fast and slow walking speed. Results Multiple system atrophy patients displayed higher gait variability except for stride time at all velocities compared with controls, while Parkinson's patients did not. Compared with Parkinson's disease, multiple system atrophy patients displayed higher variability of swing time, stride length and gait velocity at comfortable speed and at slow speed for swing and stance time, stride length and gait velocity (all P < 0.05). Stride time variability was significantly higher in slow compared to comfortable walking in patients with multiple system atrophy (P = 0.014). Variability parameters significantly correlated with the postural instability/gait difficulty subscore in both disease groups. Conversely, significant correlations between variability parameters and MDS-UPDRS III score was observed only for multiple system atrophy patients. Conclusion This analysis suggests that gait variability parameters reflect the major axial impairment and postural instability displayed by multiple system atrophy patients compared with Parkinson's disease patients and controls.
Authors with CRIS profile
Björn Eskofier
Machine Learning and Data Analytics Lab
Jochen Klucken
Department of Molecular Neurology
Heiko Gaßner
Department of Molecular Neurology
Involved external institutions
Medizinische Universität Innsbruck
Austria (AT)
Krankenhaus Bruneck / Ospedale di Brunico
Italy (IT)
Austria (AT)
Krankenhaus Bruneck / Ospedale di Brunico
Italy (IT)
How to cite
APA:
Sidoroff, V., Raccagni, C., Kaindlstorfer, C., Eschlboeck, S., Fanciulli, A., Granata, R.,... Gaßner, H. (2020). Characterization of gait variability in multiple system atrophy and Parkinson's disease. Journal of Neurology. https://dx.doi.org/10.1007/s00415-020-10355-y
MLA:
Sidoroff, Victoria, et al. "Characterization of gait variability in multiple system atrophy and Parkinson's disease." Journal of Neurology (2020).
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