Comprehensive phenotyping revealed transient startle response reduction and histopathological gadolinium localization to perineuronal nets after gadodiamide administration in rats

Habermeyer J, Boyken J, Harrer J, Canneva F, Ratz V, Moceri S, Admard J, Casadei N, Jost G, Bäuerle T, Frenzel T, Schmitz C, Schuetz G, Pietsch H, von Hörsten S (2020)

Publication Type: Journal article

Publication year: 2020

Journal

Scientific Reports Nature Publishing Group: Open Access Journals - Option B

Book Volume: 10

Journal Issue: 1

DOI: 10.1038/s41598-020-79374-z

Abstract

Gadolinium based contrast agents (GBCAs) are widely used in clinical MRI since the mid-1980s. Recently, concerns have been raised that trace amounts of Gadolinium (Gd), detected in brains even long time after GBCA application, may cause yet unrecognized clinical consequences. We therefore assessed the behavioral phenotype, neuro-histopathology, and Gd localization after repeated administration of linear (gadodiamide) or macrocyclic (gadobutrol) GBCA in rats. While most behavioral tests revealed no difference between treatment groups, we observed a transient and reversible decrease of the startle reflex after gadodiamide application. Residual Gd in the lateral cerebellar nucleus was neither associated with a general gene expression pathway deregulation nor with neuronal cell loss, but in gadodiamide-treated rats Gd was associated with the perineuronal net protein aggrecan and segregated to high molecular weight fractions. Our behavioral finding together with Gd distribution and speciation support a substance class difference for Gd presence in the brain after GBCA application.

Authors with CRIS profile

Johanna Habermeyer Professur für Experimentelle Biomedizin Veronika Ratz-Wirsching Department of Experimental Therapy Sandra Moceri Professur für Experimentelle Biomedizin Tobias Bäuerle Professur für Multimodale Bildgebung in der präklinischen Forschung Stephan von Hörsten Professur für Experimentelle Biomedizin

Involved external institutions

Bayer AG DE Germany (DE) Ludwig-Maximilians-Universität (LMU) DE Germany (DE) Eberhard Karls Universität Tübingen DE Germany (DE)

How to cite

APA:

Habermeyer, J., Boyken, J., Harrer, J., Canneva, F., Ratz, V., Moceri, S.,... von Hörsten, S. (2020). Comprehensive phenotyping revealed transient startle response reduction and histopathological gadolinium localization to perineuronal nets after gadodiamide administration in rats. Scientific Reports, 10(1). https://doi.org/10.1038/s41598-020-79374-z

MLA:

Habermeyer, Johanna, et al. "Comprehensive phenotyping revealed transient startle response reduction and histopathological gadolinium localization to perineuronal nets after gadodiamide administration in rats." Scientific Reports 10.1 (2020).

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