In-vitro mechanical and biological evaluation of novel zirconia reinforced bioglass scaffolds for bone repair

Gouveia PF, Mesquita-Guimarães J, Galárraga-Vinueza ME, Souza JC, Silva FS, Fredel MC, Boccaccini AR, Detsch R, Henriques B (2021)

Publication Type: Journal article

Publication year: 2021

Journal

Journal of the Mechanical Behavior of Biomedical Materials Elsevier

Book Volume: 114

Article Number: 104164

DOI: 10.1016/j.jmbbm.2020.104164

Abstract

Bone defects resulting from infections, tumors, or traumas represent a major health care issue. Tissue engineering has been working togehter with medicine to develop techniques to repair bone damage and increase patient's life quality. In that context, scaffolds composed of bioactive ceramics have been explored, although their poor mechanical properties restrain their clinical applications as highly porous structures. As an alternative solution, this study aimed to evaluate the mechanical properties and biological response of novel zirconia reinforced bioactive glass scaffolds (ZRBG) manufactured by the replica method. The microstructure, chemical composition, compressive strength, density, in-vitro bioactivity, and cell viability were analyzed and compared to scaffolds made of monolithic zirconia of similar architecture (45, 60 and 85 ppi). The microstructure of ZRGB scaffolds consisted of a bioactive glass matrix with dispersed zirconia particles (~33% glassy phase) and the compressive strength values (ZRBG scaffolds: 0.33 ± 0.11, 0.41 ± 0.20 and 0.48 ± 0.6 MPa; ZRBG scaffolds with extra BG coating: 0.38 ± 0.13, 0.45 ± 0.11 and 0.50 ± 0.14 MPa for 45, 60 and 80 ppi, respectively) were not statistically different from those of zirconia scaffolds (0.25 ± 0.14 MPa for 45 ppi, 0.32 ± 0.11 MPa for 60 ppi and 0.44 ± 0.07 MPa for 80 ppi). No bioactivity was exhibited by monolithic zirconia scaffolds while significant bioactive response was found for ZRBG scaffolds. The cell viability of ZRBG scaffolds in osteogenic medium was improved up to 171% over zirconia scaffolds. This work provides promosing results for further exploring this technique for implant dentistry.

Authors with CRIS profile

Aldo Boccaccini Lehrstuhl für Werkstoffwissenschaften (Biomaterialien) Rainer Detsch Lehrstuhl für Werkstoffwissenschaften (Biomaterialien)

Involved external institutions

Federal University of Santa Catarina / Universidade Federal de Santa Catarina (UFSC) BR Brazil (BR) Universidade do Minho PT Portugal (PT)

How to cite

APA:

Gouveia, P.F., Mesquita-Guimarães, J., Galárraga-Vinueza, M.E., Souza, J.C., Silva, F.S., Fredel, M.C.,... Henriques, B. (2021). In-vitro mechanical and biological evaluation of novel zirconia reinforced bioglass scaffolds for bone repair. Journal of the Mechanical Behavior of Biomedical Materials, 114. https://dx.doi.org/10.1016/j.jmbbm.2020.104164

MLA:

Gouveia, Paula F., et al. "In-vitro mechanical and biological evaluation of novel zirconia reinforced bioglass scaffolds for bone repair." Journal of the Mechanical Behavior of Biomedical Materials 114 (2021).

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