OCT-OCTA segmentation: Combining structural and blood flow information to segment bruch's membrane

Schottenhamml J, Moult EM, Ploner S, Chen S, Novais E, Husvogt L, Duker JS, Waheed NK, Fujimoto JG, Maier A (2021)

Publication Type: Journal article

Publication year: 2021

Journal

Biomedical Optics Express Optical Society of America

Book Volume: 12

Pages Range: 84-99

Journal Issue: 1

DOI: 10.1364/BOE.398222

Abstract

In this paper we present a fully automated graph-based segmentation algorithm that jointly uses optical coherence tomography (OCT) and OCT angiography (OCTA) data to segment Bruch's membrane (BM). This is especially valuable in cases where the spatial correlation between BM, which is usually not visible on OCT scans, and the retinal pigment epithelium (RPE), which is often used as a surrogate for segmenting BM, is distorted by pathology. We validated the performance of our proposed algorithm against manual segmentation in a total of 18 eyes from healthy controls and patients with diabetic retinopathy (DR), non-exudative age-related macular degeneration (AMD) (early/intermediate AMD, nascent geographic atrophy (nGA) and drusen-associated geographic atrophy (DAGA) and geographic atrophy (GA)), and choroidal neovascularization (CNV) with a mean absolute error of ∼0.91 pixel (∼4.1 µm). This paper suggests that OCT-OCTA segmentation may be a useful framework to complement the growing usage of OCTA in ophthalmic research and clinical communities.

Authors with CRIS profile

Julia Schottenhamml Lehrstuhl für Informatik 5 (Mustererkennung) Stefan Ploner Lehrstuhl für Informatik 5 (Mustererkennung) Lennart Husvogt Lehrstuhl für Informatik 5 (Mustererkennung) Andreas Maier Lehrstuhl für Informatik 5 (Mustererkennung)

Related research project(s)

Joint Iterative Reconstruction and Motion Compensation for Optical Coherence Tomography Angiography (Joint Reco & MoCo for OCT(A)) Aug. 1, 2017 - July 31, 2019

Involved external institutions

Tufts Medical Center US United States (USA) (US) Massachusetts Institute of Technology (MIT) US United States (USA) (US)

How to cite

APA:

Schottenhamml, J., Moult, E.M., Ploner, S., Chen, S., Novais, E., Husvogt, L.,... Maier, A. (2021). OCT-OCTA segmentation: Combining structural and blood flow information to segment bruch's membrane. Biomedical Optics Express, 12(1), 84-99. https://dx.doi.org/10.1364/BOE.398222

MLA:

Schottenhamml, Julia, et al. "OCT-OCTA segmentation: Combining structural and blood flow information to segment bruch's membrane." Biomedical Optics Express 12.1 (2021): 84-99.

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