Wagner A, Danko V, Federle A, Klett D, Simon D, Heiß R, Jüngert JM, Uder M, Schett G, Neurath M, Wölfle J, Waldner M, Trollmann R, Regensburger A, Knieling F (2021)
Publication Type: Journal article
Publication year: 2021
Book Volume: 21
Article Number: 100220
DOI: 10.1016/j.pacs.2020.100220
Photo-or optoacoustic imaging (OAI) allows quantitative imaging of target tissues. Using multi-wavelength illumination with subsequent ultrasound detection, it may visualize a variety of different chromophores at centimeter depth. Despite its non-invasive, label-free advantages, the precision of repeated measurements for clinical applications is still elusive. We present a multilayer analysis of n = 1920 imaging datasets obtained from a prospective clinical trial (NCT03979157) in n = 10 healthy adult volunteers. All datasets were analyzed for 13 single wavelengths (SWL) between 660 nm–1210 nm and five MSOT-parameters (deoxygenated/oxygenated/total hemoglobin, collagen and lipid) by a semi-automated batch mode software. Intraclass correlation coefficients (ICC) were good to excellent for intrarater (SWL: 0.82–0.92; MSOT-parameter: 0.72−0.92) and interrater reproducibility (SWL: 0.79−0.87; MSOT-parameter: 0.78−0.86), with the exception for MSOT-parameter lipid (interrater ICC: 0.56). Results were stable over time, but exercise-related effects as well as inter-and intramuscular variability were observed. The findings of this study provide a framework for further clinical OAI implementation.
APA:
Wagner, A., Danko, V., Federle, A., Klett, D., Simon, D., Heiß, R.,... Knieling, F. (2021). Precision of handheld multispectral optoacoustic tomography for muscle imaging. Photoacoustics, 21. https://dx.doi.org/10.1016/j.pacs.2020.100220
MLA:
Wagner, Anna, et al. "Precision of handheld multispectral optoacoustic tomography for muscle imaging." Photoacoustics 21 (2021).
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