Molecular Mechanisms to Target Cellular Senescence in Hepatocellular Carcinoma
Mittermeier C, Konopa A, Mühlich S (2020)
Publication Type: Journal article, Review article
Publication year: 2020
Journal
Book Volume: 9
Journal Issue: 12
DOI: 10.3390/cells9122540
Abstract
Hepatocellular carcinoma (HCC) has emerged as a major cause of cancer-related death and is the most common type of liver cancer. Due to the current paucity of drugs for HCC therapy there is a pressing need to develop new therapeutic concepts. In recent years, the role of Serum Response Factor (SRF) and its coactivators, Myocardin-Related Transcription Factors A and B (MRTF-A and -B), in HCC formation and progression has received considerable attention. Targeting MRTFs results in HCC growth arrest provoked by oncogene-induced senescence. The induction of senescence acts as a tumor-suppressive mechanism and therefore gains consideration for pharmacological interventions in cancer therapy. In this article, we describe the key features and the functional role of senescence in light of the development of novel drug targets for HCC therapy with a focus on MRTFs.
Authors with CRIS profile
Andreas Konopa
Professur für Molekulare und Klinische Pharmazie
Susanne Mühlich
Professur für Molekulare und Klinische Pharmazie
Involved external institutions
Singapore (SG)How to cite
APA:
Mittermeier, C., Konopa, A., & Mühlich, S. (2020). Molecular Mechanisms to Target Cellular Senescence in Hepatocellular Carcinoma. Cells, 9(12). https://dx.doi.org/10.3390/cells9122540
MLA:
Mittermeier, Constanze, Andreas Konopa, and Susanne Mühlich. "Molecular Mechanisms to Target Cellular Senescence in Hepatocellular Carcinoma." Cells 9.12 (2020).
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