Metabolic reprogramming of osteoclasts represents a therapeutic target during the treatment of osteoporosis

Taubmann J, Krishnacoumar B, Böhm C, Faas M, Müller D, Adam S, Stoll C, Böttcher M, Mougiakakos D, Sonnewald U, Hofmann J, Schett G, Krönke G, Scholtysek C (2020)

Publication Type: Journal article

Publication year: 2020

Journal

Scientific Reports Nature Publishing Group: Open Access Journals - Option B

Book Volume: 10

Article Number: 21020

Journal Issue: 1

DOI: 10.1038/s41598-020-77892-4

Abstract

Osteoclasts are specialised bone resorbing cells that control both physiological and pathological bone turnover. Functional changes in the differentiation and activity of osteoclasts are accompanied by active metabolic reprogramming. However, the biological significance and the in vivo relevance of these events has remained unclear. Here we show that bone resorption of differentiated osteoclasts heavily relies on increased aerobic glycolysis and glycolysis-derived lactate production. While pharmacological inhibition of glycolysis did not affect osteoclast differentiation or viability, it efficiently blocked bone resorption in vitro and in vivo and consequently ameliorated ovariectomy-induced bone loss. Our experiments thus highlight the therapeutic potential of interfering with osteoclast-intrinsic metabolic pathways as possible strategy for the treatment of diseases characterized by accelerated bone loss.

Authors with CRIS profile

Archana Brenda Krishnacoumar Department of Medicine 3 – Rheumatology and Immunology Christina Böhm Department of Medicine 3 – Rheumatology and Immunology Maria Faas Lehrstuhl für Biochemie Dorothea Müller Department of Medicine 3 – Rheumatology and Immunology Susanne Adam Department of Medicine 3 – Rheumatology and Immunology Martin Böttcher Department of Medicine 5 – Haematology and Oncology Dimitrios Mougiakakos Professur für Hämatologie/Onkologie mit dem Schwerpunkt Tumorimmunologie Uwe Sonnewald Lehrstuhl für Biochemie Jörg Hofmann Lehrstuhl für Biochemie Georg Schett Lehrstuhl für Innere Medizin III Gerhard Krönke Department of Medicine 3 – Rheumatology and Immunology

How to cite

APA:

Taubmann, J., Krishnacoumar, B., Böhm, C., Faas, M., Müller, D., Adam, S.,... Scholtysek, C. (2020). Metabolic reprogramming of osteoclasts represents a therapeutic target during the treatment of osteoporosis. Scientific Reports, 10(1). https://dx.doi.org/10.1038/s41598-020-77892-4

MLA:

Taubmann, Jule, et al. "Metabolic reprogramming of osteoclasts represents a therapeutic target during the treatment of osteoporosis." Scientific Reports 10.1 (2020).

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