Maximum a posteriori signal recovery for optical coherence tomography angiography image generation and denoising

Husvogt L, Ploner S, Chen S, Stromer D, Schottenhamml J, Alibhai AY, Moult E, Waheed NK, Fujimoto JG, Maier A (2021)

Publication Language: English

Publication Type: Journal article, Original article

Publication year: 2021

Journal

Book Volume: 12

Pages Range: 55-68

Journal Issue: 1

URI: https://www.osapublishing.org/boe/fulltext.cfm?uri=boe-12-1-55&id=444277

DOI: 10.1364/BOE.408903

Open Access Link: https://www.osapublishing.org/boe/fulltext.cfm?uri=boe-12-1-55&id=444277

Abstract

Optical coherence tomography angiography (OCTA) is a novel and clinically promising imaging modality to image retinal and sub-retinal vasculature. Based on repeated optical coherence tomography (OCT) scans, intensity changes are observed over time and used to compute OCTA image data. OCTA data are prone to noise and artifacts caused by variations in flow speed and patient movement. We propose a novel iterative maximum a posteriori signal recovery algorithm in order to generate OCTA volumes with reduced noise and increased image quality. This algorithm is based on previous work on probabilistic OCTA signal models and maximum likelihood estimates. Reconstruction results using total variation minimization and wavelet shrinkage for regularization were compared against an OCTA ground truth volume, merged from six co-registered single OCTA volumes. The results show a significant improvement in peak signal-to-noise ratio and structural similarity. The presented algorithm brings together OCTA image generation and Bayesian statistics and can be developed into new OCTA image generation and denoising algorithms.

Authors with CRIS profile

Related research project(s)

Involved external institutions

Massachusetts Institute of Technology (MIT) United States (USA) (US) Tufts Medical Center United States (USA) (US)

How to cite

APA:

Husvogt, L., Ploner, S., Chen, S., Stromer, D., Schottenhamml, J., Alibhai, A.Y.,... Maier, A. (2021). Maximum a posteriori signal recovery for optical coherence tomography angiography image generation and denoising. Biomedical Optics Express, 12(1), 55-68. https://dx.doi.org/10.1364/BOE.408903

MLA:

Husvogt, Lennart, et al. "Maximum a posteriori signal recovery for optical coherence tomography angiography image generation and denoising." Biomedical Optics Express 12.1 (2021): 55-68.

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