Tumour-infiltrating inflammatory cells in early breast cancer: An underrated prognostic and predictive factor?
Schnellhardt S, Erber R, Büttner-Herold M, Rosahl MC, Ott O, Strnad V, Beckmann M, King L, Hartmann A, Fietkau R, Distel L (2020)
Publication Type: Journal article
Publication year: 2020
Journal
Book Volume: 21
Pages Range: 1-17
Article Number: 8238
Journal Issue: 21
DOI: 10.3390/ijms21218238
Abstract
The role of tumour-infiltrating inflammatory cells (TIICs) in the disease progression of hormone-receptor-positive breast cancer (HR+ BC) is largely unclear since it is generally regarded as the least immunogenic BC subtype. This study investigated the prognostic significance of CD1a+ dendritic cells, CD20+ B cells, CD45RO+ memory T cells and CD4+ T-helper cells in HR+ BC. One hundred and forty-six patients were treated for early stage, distant-metastases-free HR+ BC in an accelerated partial breast irradiation (APBI) phase II trial. Immunohistochemistry was used to double-stain two adjoining sets of tissue microarrays from pre-RT (radiotherapy) tumour resection samples for CD1a/CD20 and CD45RO/CD4. Cell densities of CD1a+, CD20+, CD45RO+ and CD4+ TIICs in the stromal and intraepithelial compartment were registered semiautomatically. High densities of CD20+ and CD4+ TIICs were strongly associated with reduced disease-free survival (DFS), while high stromal CD45RO+ TIIC densities were indicators of subsequent successful treatment. An immunoscore based on CD20+ and CD45RO+ TIIC densities identified three different risk groups (p < 0.001). Thus, contrary to current assumptions, intratumoural immune cell composition might be an important prognostic indicator and a possible contributing factor in the outcome of HR+ BC and should be the subject of further research. Specifically, B-cell infiltration entailed an increased relapse rate and could play an important role in disease progression.
Authors with CRIS profile
Ramona Erber
Institute of Pathology
Maike Büttner-Herold
Department of Nephropathology
Oliver Ott
Medizinische Fakultät
Matthias Beckmann
Lehrstuhl für Geburtshilfe und Frauenheilkunde
Arndt Hartmann
Lehrstuhl für Allgemeine Pathologie und Pathologische Anatomie
Rainer Fietkau
Lehrstuhl für Strahlentherapie
Luitpold Distel
Department of Radiation Oncology
Involved external institutions
Australia (AU)How to cite
APA:
Schnellhardt, S., Erber, R., Büttner-Herold, M., Rosahl, M.C., Ott, O., Strnad, V.,... Distel, L. (2020). Tumour-infiltrating inflammatory cells in early breast cancer: An underrated prognostic and predictive factor? International Journal of Molecular Sciences, 21(21), 1-17. https://dx.doi.org/10.3390/ijms21218238
MLA:
Schnellhardt, Sören, et al. "Tumour-infiltrating inflammatory cells in early breast cancer: An underrated prognostic and predictive factor?" International Journal of Molecular Sciences 21.21 (2020): 1-17.
BibTeX: Download