Successful cyclosporin and ustekinumab combination therapy in a patient with severe steroid-refractory ulcerative colitis

Ganzleben I, Geppert CI, Osaba L, Hirschmann S, Nägel A, Glück C, Hoffman A, Rath T, Nagore D, Neurath M, Atreya R (2020)

Publication Type: Journal article

Publication year: 2020

Journal

Therapeutic Advances in Gastroenterology SAGE Publications

Book Volume: 13

DOI: 10.1177/1756284820954112

Abstract

The therapeutic management of patients with severe steroid-refractory ulcerative colitis still represents a critical clinical challenge. In this setting, cyclosporin is an effective and rapidly acting induction treatment that is applied in combination with maintenance therapeutic agents like thiopurines or vedolizumab. Here, we present the case of a 33-year-old ulcerative colitis patient with severe steroid-refractory ulcerative colitis who refused surgical intervention and previously demonstrated no long-term benefit to anti-TNF antibody, vedolizumab, cyclosporin, thiopurines or tofacitinib treatment. Intravenous cyclosporin therapy was re-initiated in the patient and, after signs of clinical response, therapy with ustekinumab was additionally applied. After 11 weeks of well tolerated cyclosporin and ustekinumab combination therapy, cyclosporin was discontinued upon clinical and endoscopic remission. Subsequently, ustekinumab treatment has been effective in maintaining remission during the follow-up period of 195 days.

Authors with CRIS profile

Ingo Ganzleben Department of Medicine 1 – Gastroenterology, Pneumology and Endocrinology Carol-Immanuel Geppert Institute of Pathology Simon Hirschmann Department of Medicine 1 – Gastroenterology, Pneumology and Endocrinology Timo Rath Department of Medicine 1 – Gastroenterology, Pneumology and Endocrinology Markus Neurath Lehrstuhl für Innere Medizin I Raja Atreya Professur für Translationale Immunforschung bei chronisch entzündlichen Darmerkrankungen (Heisenberg-Professur)

Involved external institutions

Grifols, S.A. ES Spain (ES) Klinikum Aschaffenburg - Alzenau DE Germany (DE)

How to cite

APA:

Ganzleben, I., Geppert, C.-I., Osaba, L., Hirschmann, S., Nägel, A., Glück, C.,... Atreya, R. (2020). Successful cyclosporin and ustekinumab combination therapy in a patient with severe steroid-refractory ulcerative colitis. Therapeutic Advances in Gastroenterology, 13. https://doi.org/10.1177/1756284820954112

MLA:

Ganzleben, Ingo, et al. "Successful cyclosporin and ustekinumab combination therapy in a patient with severe steroid-refractory ulcerative colitis." Therapeutic Advances in Gastroenterology 13 (2020).

BibTeX: Download