Hybrid gelatin/oxidized chondroitin sulfate hydrogels incorporating bioactive glass nanoparticles with enhanced mechanical properties, mineralization, and osteogenic differentiation
Zhou L, Fan L, Zhang FM, Jiang Y, Cai M, Dai C, Luo YA, Tu LJ, Zhou ZN, Li XJ, Ning CY, Zheng K, Boccaccini AR, Tan GX (2021)
Publication Type: Journal article
Publication year: 2021
Journal
Book Volume: 6
Pages Range: 890-904
Journal Issue: 3
DOI: 10.1016/j.bioactmat.2020.09.012
Abstract
Biopolymer based hydrogels are characteristic of their biocompatibility and capability of mimicking extracellular matrix structure to support cellular behavior. However, these hydrogels suffer from low mechanical properties, uncontrolled degradation, and insufficient osteogenic activity, which limits their applications in bone regeneration. In this study, we developed hybrid gelatin (Gel)/oxidized chondroitin sulfate (OCS) hydrogels that incorporated mesoporous bioactive glass nanoparticles (MBGNs) as bioactive fillers for bone regeneration. Gel-OCS hydrogels could be self-crosslinked in situ under physiological conditions in the presence of borax. The incorporation of MBGNs enhanced the crosslinking and accelerated the gelation. The gelation time decreased with increasing the concentration of MBGNs added. Incorporation of MBGNs in the hydrogels significantly improved the mechanical properties in terms of enhanced storage modulus and compressive strength. The injectability of the hydrogels was not significantly affected by the MBGN incorporation. Also, the proliferation and osteogenic differentiation of rat bone marrow mesenchymal stem cells in vitro and rat cranial defect restoration in vivo were significantly promoted by the hydrogels in the presence of MBGNs. The hybrid Gel-OCS/MBGN hydrogels show promising potential as injectable biomaterials or scaffolds for bone regeneration/repair applications given their tunable degradation and gelation behavior as well as favorable mechanical behavior and osteogenic activities.
Authors with CRIS profile
Kai Zheng
Lehrstuhl für Werkstoffwissenschaften (Biomaterialien)
Aldo Boccaccini
Lehrstuhl für Werkstoffwissenschaften (Biomaterialien)
Involved external institutions
Guangdong University of Technology
China (CN)
South China University of Technology (SCUT) / 华南理工大学
China (CN)
State University of New York at Albany (UNY Albany / UAlbany)
United States (USA) (US)
Sun Yat-Sen University
China (CN)
China (CN)
South China University of Technology (SCUT) / 华南理工大学
China (CN)
State University of New York at Albany (UNY Albany / UAlbany)
United States (USA) (US)
Sun Yat-Sen University
China (CN)
How to cite
APA:
Zhou, L., Fan, L., Zhang, F.M., Jiang, Y., Cai, M., Dai, C.,... Tan, G.X. (2021). Hybrid gelatin/oxidized chondroitin sulfate hydrogels incorporating bioactive glass nanoparticles with enhanced mechanical properties, mineralization, and osteogenic differentiation. Bioactive Materials, 6(3), 890-904. https://dx.doi.org/10.1016/j.bioactmat.2020.09.012
MLA:
Zhou, Lei, et al. "Hybrid gelatin/oxidized chondroitin sulfate hydrogels incorporating bioactive glass nanoparticles with enhanced mechanical properties, mineralization, and osteogenic differentiation." Bioactive Materials 6.3 (2021): 890-904.
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