Mitoxantrone-loaded zeolite beta nanoparticles: Preparation, physico-chemical characterization and biological evaluation
Grund S, Doussineau T, Fischer D, Mohr GJ (2012)
Publication Type: Journal article
Publication year: 2012
Journal
Book Volume: 365
Pages Range: 33-40
Journal Issue: 1
DOI: 10.1016/j.jcis.2011.09.003
Abstract
This article describes the preparation and the physico-chemical characterization of a new host-guest system consisting of zeolite beta nanoparticles as host and mitoxantrone as guest. The resulting host-guest system mitoxantrone@. beta is characterized in terms of morphology (transmission electron microscopy, dynamic light scattering), structure (powder wide-angle X-ray diffraction, nitrogen sorption), surface charge (ξ-potential measurements), and optical properties (UV-visible absorption, steady-state fluorescence). Mitoxantrone@. beta particles are monodisperse in size with a mean diameter centered around 100. nm. Mitoxantrone guest molecules are adsorbed at the micropore entrances of zeolite host. Resulting nanoparticles retrieve the interesting optical properties of guest molecules with a fluorescence emission band in the near-infrared region. Mitoxantrone loading is comparatively evaluated by three different means (elemental analysis, direct and indirect UV-visible absorption studies) showing a loading level of 6.8. μmol/g. Mitoxantrone@. beta nanoparticles also show a noticeable cytotoxic effect when applied to cancer cells. © 2011 Elsevier Inc.
Authors with CRIS profile
Involved external institutions
Friedrich-Schiller-Universität Jena
Germany (DE)
Fraunhofer-Einrichtung für Mikrosysteme und Festkörper-Technologien (EMFT) / Fraunhofer Research Institution for Microsystems and Solid State Technologies
Germany (DE)
Germany (DE)
Fraunhofer-Einrichtung für Mikrosysteme und Festkörper-Technologien (EMFT) / Fraunhofer Research Institution for Microsystems and Solid State Technologies
Germany (DE)
How to cite
APA:
Grund, S., Doussineau, T., Fischer, D., & Mohr, G.J. (2012). Mitoxantrone-loaded zeolite beta nanoparticles: Preparation, physico-chemical characterization and biological evaluation. Journal of Colloid and Interface Science, 365(1), 33-40. https://dx.doi.org/10.1016/j.jcis.2011.09.003
MLA:
Grund, Stefan, et al. "Mitoxantrone-loaded zeolite beta nanoparticles: Preparation, physico-chemical characterization and biological evaluation." Journal of Colloid and Interface Science 365.1 (2012): 33-40.
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