Loading of bacterial nanocellulose hydrogels with proteins using a high-speed technique
Mueller A, Wesarg F, Hessler N, Mueller FA, Kralisch D, Fischer D (2014)
Publication Type: Journal article
Publication year: 2014
Journal
Book Volume: 106
Pages Range: 410-413
Journal Issue: 1
DOI: 10.1016/j.carbpol.2014.01.038
Abstract
For the loading of the natural biopolymer bacterial nanocellulose (BNC) with drugs, usually an adsorption method has been described. In the present study, a high-speed loading technique based on vortexing was established for the incorporation of proteins in BNC as drug delivery system. Compared to the conventional technique, vortexing accomplished in 10 min the same protein loading capacity as the adsorption method in 24 h with comparable protein distribution and protein stability. Vortex loaded BNC demonstrated a retarded protein release with a lower total amount of released protein after 168 h compared to the adsorption loaded BNC. This was correlated with a densification of the fiber network as shown by electron microscopy and a reduced water holding capacity. These observations offer the possibility to control the drug release by selection of the preparation technique. © 2014 Elsevier Ltd.
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Germany (DE)How to cite
APA:
Mueller, A., Wesarg, F., Hessler, N., Mueller, F.A., Kralisch, D., & Fischer, D. (2014). Loading of bacterial nanocellulose hydrogels with proteins using a high-speed technique. Carbohydrate Polymers, 106(1), 410-413. https://dx.doi.org/10.1016/j.carbpol.2014.01.038
MLA:
Mueller, Astrid, et al. "Loading of bacterial nanocellulose hydrogels with proteins using a high-speed technique." Carbohydrate Polymers 106.1 (2014): 410-413.
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