Luminomagnetic Eu3 +- and Dy3 +-doped hydroxyapatite for multimodal imaging

Tesch A, Wenisch C, Herrmann KH, Reichenbach JR, Warncke P, Fischer D, Mueller FA (2017)

Publication Type: Journal article

Publication year: 2017

Journal

Materials Science and Engineering C Elsevier

Book Volume: 81

Pages Range: 422-431

DOI: 10.1016/j.msec.2017.08.032

Abstract

Multimodal imaging has recently attracted much attention due to the advantageous combination of different imaging modalities, like photoluminescence (PL) and magnetic resonance imaging (MRI). In the present study, luminescent and magnetic hydroxyapatites (HAp) were prepared via doping with europium (Eu^{3 +}) and dysprosium (Dy^{3 +}), respectively. Co-doping of Eu^{3 +} and Dy^{3 +} was used to combine the desired physical properties. Both lanthanide ions were successfully incorporated in the HAp crystal lattice, where they preferentially occupied calcium(I) sites. While Eu-doped HAp (Eu:HAp) exhibits dopant concentration dependent persistent PL properties, Dy-doped HAp (Dy:HAp) shows paramagnetic behavior due to the high magnetic moment of Dy^{3 +}. Co-doped HAp (Eu:Dy:HAp) nanoparticles combine both properties in one single crystal. Remarkably, multimodal co-doped HAp features enhanced PL properties due to an energy transfer from Dy^{3 +} sensitizer to Eu^{3 +} activator ions. Eu:Dy:HAp exhibits strong transverse relaxation effects with a maximum transverse relaxivity of 83.3 L/(mmol·s). Due to their tunable PL, magnetic properties and cytocompatibility Eu:-, Dy:- and Eu:Dy:HAp represent promising biocompatible ceramic materials for luminescence imaging that simultaneously may serve as a contrast agent for MRI in permanent implants or functional coatings.

Authors with CRIS profile

Dagmar Fischer

Involved external institutions

Universitätsklinikum Jena

Germany (DE) Friedrich-Schiller-Universität Jena

Germany (DE)

How to cite

APA:

Tesch, A., Wenisch, C., Herrmann, K.-H., Reichenbach, J.R., Warncke, P., Fischer, D., & Mueller, F.A. (2017). Luminomagnetic Eu3 +- and Dy3 +-doped hydroxyapatite for multimodal imaging. Materials Science and Engineering C, 81, 422-431. https://doi.org/10.1016/j.msec.2017.08.032

MLA:

Tesch, Annemarie, et al. "Luminomagnetic Eu3 +- and Dy3 +-doped hydroxyapatite for multimodal imaging." Materials Science and Engineering C 81 (2017): 422-431.

BibTeX: Download