Paramagnetic, NIR-luminescent Nd3+- and Gd3+-doped fluorapatite as contrast agent for multimodal biomedical imaging

Tesch A, Roeder R, Zapf M, Ronning C, Warncke P, Fischer D, Herrmann KH, Reichenbach JR, Mueller FA (2018)

Publication Type: Journal article

Publication year: 2018

Journal

Journal of the American Ceramic Society Wiley-Blackwell

Book Volume: 101

Pages Range: 4441-4446

Journal Issue: 10

DOI: 10.1111/jace.15736

Abstract

Combining near infrared (NIR) luminescence and magnetic resonance (MR) contrasts in a crystal host is highly desirable for contrast agents in biomedical imaging technology, as it will enable multimodal imaging processes. In the present work, biocompatible luminescent and paramagnetic fluorapatite (FAp) nanoparticles were prepared via doping with neodymium (Nd3+) and gadolinium (Gd3+), respectively. While Nd3+-doped FAp (Nd:FAp) exhibits dopant concentration-dependent photoluminescence (PL) in the NIR spectral region, Gd3+-doped FAp (Gd:FAp) shows paramagnetic behavior and strong transverse relaxation effects resulting in MR contrastive properties. Remarkably, multimodal co-doped FAp (Nd:Gd:FAp) nanoparticles combine both properties in 1 single crystal enabling luminescence as well as MR contrast.

Authors with CRIS profile

Dagmar Fischer

Involved external institutions

Friedrich-Schiller-Universität Jena DE Germany (DE) Universitätsklinikum Jena DE Germany (DE)

How to cite

APA:

Tesch, A., Roeder, R., Zapf, M., Ronning, C., Warncke, P., Fischer, D.,... Mueller, F.A. (2018). Paramagnetic, NIR-luminescent Nd3+- and Gd3+-doped fluorapatite as contrast agent for multimodal biomedical imaging. Journal of the American Ceramic Society, 101(10), 4441-4446. https://dx.doi.org/10.1111/jace.15736

MLA:

Tesch, Annemarie, et al. "Paramagnetic, NIR-luminescent Nd3+- and Gd3+-doped fluorapatite as contrast agent for multimodal biomedical imaging." Journal of the American Ceramic Society 101.10 (2018): 4441-4446.

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