Tailor-made material characteristics of bacterial cellulose for drug delivery applications in dentistry
Weyell P, Beekmann U, Kuepper C, Dederichs M, Thamm J, Fischer D, Kralisch D (2019)
Publication Type: Journal article
Publication year: 2019
Journal
Book Volume: 207
Pages Range: 1-10
DOI: 10.1016/j.carbpol.2018.11.061
Abstract
Bacterial cellulose (BC) has shown high potential as innovative wound dressing and drug delivery system. Bringing both together, drug-loaded BC was investigated for applications in dental therapies such as dental extraction or mucosal transplantation. Both applications would benefit from a material which degrades under physiological conditions, and from an antibiotic environment. Consequently, periodate-oxidation of BC was investigated to facilitate modified degradation behaviour. A periodate concentration of 0.14 mol/L at ϑ = 25 °C and t = 8 h resulted in a material loss of <10%, but at the same time a sufficient degree of degradation. Additionally, native and oxidised BC loaded with doxycycline was tested for prophylaxis against infection. An in vitro-toxicity test (MTT assay) provided a first confirmation of biocompatibility, whereas agar diffusion tests proved antibiotic efficiency against pathogenic oral bacteria. Release studies of the drug from native and oxidised BC confirmed a comparative biphasic release behaviour.
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Germany (DE)How to cite
APA:
Weyell, P., Beekmann, U., Kuepper, C., Dederichs, M., Thamm, J., Fischer, D., & Kralisch, D. (2019). Tailor-made material characteristics of bacterial cellulose for drug delivery applications in dentistry. Carbohydrate Polymers, 207, 1-10. https://doi.org/10.1016/j.carbpol.2018.11.061
MLA:
Weyell, Peter, et al. "Tailor-made material characteristics of bacterial cellulose for drug delivery applications in dentistry." Carbohydrate Polymers 207 (2019): 1-10.
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