Physical Activity and Exercise in Mild Cognitive Impairment and Dementia: An Umbrella Review of Intervention and Observational Studies

Demurtas J, Schöne D, Torbahn G, Marengoni A, Grande G, Zou L, Petrovic M, Maggi S, Cesari M, Lamb S, Soysal P, Kemmler W, Sieber C, Mueller C, Shenkin SD, Schwingshackl L, Smith L, Veronese N (2020)

Publication Type: Journal article, Review article

Publication year: 2020

Journal

Book Volume: 21

Pages Range: 1415-1422.e6

Journal Issue: 10

DOI: 10.1016/j.jamda.2020.08.031

Abstract

Objectives: The aim of this umbrella review was to determine the effect of physical activity/exercise on improving cognitive and noncognitive outcomes in people with MCI (mild cognitive impairment) and dementia. Design: Umbrella review of systematic reviews (SR), with or without meta-analyses (MAs), of randomized controlled trials (RCTs) and observational studies. Settings and Participants: People with MCI or dementia, confirmed through validated assessment measures. Any form of physical activity/exercise was included. As controls, we included participants not following any prespecified physical activity/exercise intervention or following the same standard protocol with the intervention group. Methods: The protocol was registered in PROSPERO (CDR 164197). Major databases were searched until December 31, 2019. The certainty of evidence of statistically significant outcomes was evaluated using the Grading of Recommendations Assessment, Development and Evaluation approach. SRs' findings, without a formal MA, were reported descriptively. Results: Among 1160 articles initially evaluated, 27 SRs (all of RCTs, 9 without MA) for a total of 28,205 participants with MCI/dementia were included. In patients with MCI, mind-body intervention (standardized mean difference [SMD] = 0.36; 95% confidence intervals [CI] 0.20–0.52; low certainty) and mixed physical activity interventions (SMD = 0.30; 95% CI 0.11–0.49; moderate certainty) had a small effect on global cognition, whereas resistance training (SMD = 0.80; 95% CI 0.29–1.31; very low certainty) had a large effect on global cognition. In people affected by dementia, physical activity/exercise was effective in improving global cognition in Alzheimer disease (SMD = 1.10; 95% CI 0.65–1.64; very low certainty) and in all types of dementia (SMD = 0.48; 95% CI 0.22–0.74; low certainty). Finally, physical activity/exercise improved noncognitive outcomes in people with dementia including falls, and neuropsychiatric symptoms. Conclusions and Implications: Supported by very low-to-moderate certainty of evidence, physical activity/exercise has a positive effect on several cognitive and noncognitive outcomes in people with MCI and dementia, but RCTs, with low risk of bias/confounding, are still needed to confirm these relationships.

Authors with CRIS profile

Involved external institutions

Azienda Usl Toscana sud est Italy (IT) Università degli Studi di Brescia Italy (IT) Stockholm University / Stockholms universitet Sweden (SE) Shenzhen University (SZU) / 深圳大学 China (CN) Universiteit Gent (UGent) / Ghent University Belgium (BE) Consiglio Nazionale delle Ricerche (CNR) / National Research Council of Italy Italy (IT) Università degli studi di Milano Italy (IT) University of Oxford United Kingdom (GB) Bezmialem University / Bezmiâlem Vakıf Üniversitesi Turkey (TR) King’s College London United Kingdom (GB) University of Edinburgh United Kingdom (GB) Albert-Ludwigs-Universität Freiburg Germany (DE) Anglia Ruskin University United Kingdom (GB) Azienda Ulss 3 Serenissima Italy (IT)

How to cite

APA:

Demurtas, J., Schöne, D., Torbahn, G., Marengoni, A., Grande, G., Zou, L.,... Veronese, N. (2020). Physical Activity and Exercise in Mild Cognitive Impairment and Dementia: An Umbrella Review of Intervention and Observational Studies. Journal of the American Medical Directors Association, 21(10), 1415-1422.e6. https://dx.doi.org/10.1016/j.jamda.2020.08.031

MLA:

Demurtas, Jacopo, et al. "Physical Activity and Exercise in Mild Cognitive Impairment and Dementia: An Umbrella Review of Intervention and Observational Studies." Journal of the American Medical Directors Association 21.10 (2020): 1415-1422.e6.

BibTeX: Download