In vitro evaluation of poly (vinyl alcohol)/collagen blended hydrogels for regulating human periodontal ligament fibroblasts and gingival fibroblasts
Zhou T, Zheng K, Sui B, Boccaccini AR, Sun J (2020)
Publication Type: Journal article
Publication year: 2020
Journal
Book Volume: 163
Pages Range: 1938-1946
DOI: 10.1016/j.ijbiomac.2020.09.033
Abstract
Periodontitis is a chronic inflammatory disease that can destroy periodontal tissue. Guided tissue regeneration (GTR) is widely applied to treat periodontitis. However, the challenge is to develop a GTR membrane capable of simultaneously regenerating periodontal tissue and preventing epithelial downgrowth into the defect. Herein, blended hydrogels composed of polyvinyl alcohol (PVA) and fish collagen (Col) were prepared as GTR membranes. The morphology, Col release, and cellular behavior of the blended hydrogels were evaluated. The results showed that the surface porosity and Col release of the PVA/Col blended hydrogels were enhanced by increasing the Col concentration. The adhesion and proliferation of human periodontal ligament fibroblasts (HPDLFs) and human gingival fibroblasts (HGFs) on the PVA/Col blended hydrogels can be regulated by tuning the PVA/Col ratio. The PVA/Col (50:50) blended hydrogel exhibited the highest cell proliferation rate for HPDLFs with spread cell morphology; the lowest viability for HGFs was found on the PVA/Col (100:0) hydrogel. Thus, by controlling the ratio of PVA to Col, multifunctional PVA/Col blended hydrogels able to regulate the cellular behavior of HPDLFs and HGFs can be developed, demonstrating their potential as GTR membrances for guiding periodontal tissue regeneration.
Authors with CRIS profile
Kai Zheng
Lehrstuhl für Werkstoffwissenschaften (Biomaterialien)
Aldo Boccaccini
Lehrstuhl für Werkstoffwissenschaften (Biomaterialien)
Involved external institutions
China (CN)How to cite
APA:
Zhou, T., Zheng, K., Sui, B., Boccaccini, A.R., & Sun, J. (2020). In vitro evaluation of poly (vinyl alcohol)/collagen blended hydrogels for regulating human periodontal ligament fibroblasts and gingival fibroblasts. International Journal of Biological Macromolecules, 163, 1938-1946. https://dx.doi.org/10.1016/j.ijbiomac.2020.09.033
MLA:
Zhou, Tian, et al. "In vitro evaluation of poly (vinyl alcohol)/collagen blended hydrogels for regulating human periodontal ligament fibroblasts and gingival fibroblasts." International Journal of Biological Macromolecules 163 (2020): 1938-1946.
BibTeX: Download