Ultrasensitive molecular imaging of intestinal mucosal inflammation using leukocyte-mimicking particles targeted to MAdCAM-1 in mice

Fournier AP, De Lizarrondo SM, Rateau A, Gerard-Brisou A, Waldner M, Neurath M, Vivien D, Docagne F, Gauberti M (2020)

Publication Type: Journal article

Publication year: 2020

Journal

Science Translational Medicine American Association for the Advancement of Science

Book Volume: 12

Journal Issue: 560

DOI: 10.1126/scitranslmed.aaz4047

Abstract

Mucosal tissues play critical roles in health and disease as the primary barrier between the external world and the inner body, lining the digestive, respiratory, urinary, mammary, and reproductive tracts. Clinical evaluation of mucosal tissues is currently performed using endoscopy, such as ileocolonoscopy for the intestinal mucosa, which causes substantial patient discomfort and can lead to organ damage. Here, we developed a contrast agent for molecular magnetic resonance imaging (MRI) that is targeted to mucosal vascular addressin cell adhesion molecule 1 (MAdCAM-1), an adhesion molecule overexpressed by inflamed mucosal tissues. We investigated the diagnostic performance of molecular MRI of MAdCAM-1 to detect mucosal inflammation in several models of acute and chronic intestinal inflammation in mice. We demonstrated that molecular MRI of MAdCAM-1 reveals disease activity and can evaluate the response to inflammatory treatments along the whole intestinal mucosa in clinically relevant models of inflammatory bowel diseases. We also provide evidence that this technique can detect low, subclinical mucosal inflammation. Molecular MRI of MAdCAM-1 has potential applications in early diagnosis, longitudinal follow-up, and therapeutic response monitoring in diseases affecting mucosal tissues, such as inflammatory bowel diseases.

Authors with CRIS profile

Maximilian Waldner Professur für Funktionelle Bildgebung in der Medizin Markus Neurath Lehrstuhl für Innere Medizin I

Involved external institutions

Université de Caen Basse-Normandie FR France (FR) Centre Hospitalier Universitaire de Caen FR France (FR)

How to cite

APA:

Fournier, A.P., De Lizarrondo, S.M., Rateau, A., Gerard-Brisou, A., Waldner, M., Neurath, M.,... Gauberti, M. (2020). Ultrasensitive molecular imaging of intestinal mucosal inflammation using leukocyte-mimicking particles targeted to MAdCAM-1 in mice. Science Translational Medicine, 12(560). https://doi.org/10.1126/scitranslmed.aaz4047

MLA:

Fournier, Antoine P., et al. "Ultrasensitive molecular imaging of intestinal mucosal inflammation using leukocyte-mimicking particles targeted to MAdCAM-1 in mice." Science Translational Medicine 12.560 (2020).

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