Formation of atherosclerotic lesions is independent of eosinophils in male mice

Hofheinz K, Seibert F, Ackermann J, Dietel B, Tauchi M, Oszvar-Kozma M, Kühn H, Schett G, Binder CJ, Krönke G (2020)

Publication Type: Journal article

Publication year: 2020

Journal

Atherosclerosis Elsevier

Book Volume: 311

Pages Range: 67-72

DOI: 10.1016/j.atherosclerosis.2020.08.030

Abstract

Background and aims: Oxidation of low-density lipoprotein (LDL) and oxidized LDL-mediated activation of the innate immune system have been recognized as early key events during the pathogenesis of atherosclerosis. Recent evidence identified eosinophils as a major source of enzymatic lipid oxidation and suggested a potential role of type 2 immunity in atherogenesis. However, the involvement of individual type 2 immune cell subsets involved in this process has been incompletely defined. We therefore sought to determine the role of eosinophils during LDL oxidation and the pathogenesis of this disease. Methods: Using eosinophil-deficient dblGATA1 mice, we studied the role of eosinophils in two established mouse models of atherosclerosis. Results: These experiments revealed that the presence of eosinophils did neither affect biomarkers of LDL oxidation nor atherosclerotic lesion development. Conclusions: The obtained results show that LDL oxidation and development of atherosclerosis are largely independent of eosinophils or eosinophil-mediated LDL oxidation.

Authors with CRIS profile

Fabian Seibert Department of Medicine 3 – Rheumatology and Immunology Jochen Ackermann Department of Medicine 3 – Rheumatology and Immunology Barbara Dietel Graduiertenzentrum der FAU Miyuki Tauchi-Brück Department of Medicine 2 – Cardiology and Angiology Georg Schett Lehrstuhl für Innere Medizin III Gerhard Krönke Department of Medicine 3 – Rheumatology and Immunology

Involved external institutions

Charité - Universitätsmedizin Berlin DE Germany (DE) Medizinische Universität Wien AT Austria (AT)

How to cite

APA:

Hofheinz, K., Seibert, F., Ackermann, J., Dietel, B., Tauchi, M., Oszvar-Kozma, M.,... Krönke, G. (2020). Formation of atherosclerotic lesions is independent of eosinophils in male mice. Atherosclerosis, 311, 67-72. https://dx.doi.org/10.1016/j.atherosclerosis.2020.08.030

MLA:

Hofheinz, Katharina, et al. "Formation of atherosclerotic lesions is independent of eosinophils in male mice." Atherosclerosis 311 (2020): 67-72.

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