Impact of fibroblast growth factor receptor 1 (FGFR1) amplification on the prognosis of breast cancer patients

Erber R, Rübner M, Davenport S, Hauke S, Beckmann M, Hartmann A, Häberle L, Gaß P, Press MF, Fasching P (2020)

Publication Type: Journal article

Publication year: 2020

Journal

Breast Cancer Research and Treatment Springer Verlag (Germany)

DOI: 10.1007/s10549-020-05865-2

Abstract

Purpose: Various aberrations in the fibroblast growth factor receptor genes FGFR1, FGFR2, and FGFR3 are found in different cancers, including breast cancer (BC). This study analyzed the impact of FGFR amplification on the BC prognosis. Methods: The study included 894 BC patients. The amplification rates of FGFR1, FGFR2, and FGFR3 were evaluated on tissue microarrays using fluorescence in situ hybridization (FISH). Associations between these parameters and prognosis were analyzed using multivariate Cox regression analyses. Results: FGFR1 FISH was assessable in 503 samples, FGFR2 FISH in 447, and FGFR3 FISH in 562. The FGFR1 amplification rate was 6.6% (n = 33). Increased FGFR2 copy numbers were seen in 0.9% (n = 4); only one patient had FGFR3 amplification (0.2%). Most patients with FGFR1 amplification had luminal B-like tumors (69.7%, n = 23); only 32.6% (n = 153) of patients without FGFR1 amplification had luminal B-like BC. Other patient and tumor characteristics appeared similar between these two groups. Observed outcome differences between BC patients with and without FGFR1 amplification did not achieve statistical significance; however, there was a trend toward poorer distant metastasis-free survival in BC patients with FGFR1 amplification (HR = 2.08; 95% CI 0.98 to 4.39, P = 0.05). Conclusion: FGFR1 amplification occurs most frequently in patients with luminal B-like BC. The study showed a nonsignificant correlation with the prognosis, probably due to the small sample size. Further research is therefore needed to address the role of FGFR1 amplifications in early BC patients. FGFR2 and FGFR3 amplifications are rare in patients with primary BC.

Authors with CRIS profile

Ramona Erber Institute of Pathology Matthias Rübner Department of Obstetrics and Gynaecology Matthias Beckmann Lehrstuhl für Geburtshilfe und Frauenheilkunde Arndt Hartmann Lehrstuhl für Allgemeine Pathologie und Pathologische Anatomie Paul Gaß Department of Obstetrics and Gynaecology Peter Fasching Professur für Translationale Frauenheilkunde und Geburtshilfe

Involved external institutions

Keck School of Medicine of USC US United States (USA) (US) ZytoVision GmbH DE Germany (DE)

How to cite

APA:

Erber, R., Rübner, M., Davenport, S., Hauke, S., Beckmann, M., Hartmann, A.,... Fasching, P. (2020). Impact of fibroblast growth factor receptor 1 (FGFR1) amplification on the prognosis of breast cancer patients. Breast Cancer Research and Treatment. https://dx.doi.org/10.1007/s10549-020-05865-2

MLA:

Erber, Ramona, et al. "Impact of fibroblast growth factor receptor 1 (FGFR1) amplification on the prognosis of breast cancer patients." Breast Cancer Research and Treatment (2020).

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