Dissecting the mechanism of action of intravenous immunoglobulin in human autoimmune disease: Lessons from therapeutic modalities targeting Fcγ receptors
Shock A, Humphreys D, Nimmerjahn F (2020)
Publication Type: Journal article
Publication year: 2020
Journal
Book Volume: 146
Pages Range: 492-500
Journal Issue: 3
DOI: 10.1016/j.jaci.2020.06.036
Abstract
Since the first description of the administration of high doses of pooled serum IgG, also referred to as intravenous IgG (IVIg) therapy, as being able to ameliorate various autoimmune diseases, researchers have been investigating which molecular and cellular pathways underlie IVIg activity. Apart from trying to understand the obvious conundrum that IgG can trigger both autoimmune pathology and resolution of inflammation, the rapidly expanding use of IVIg has led to a lack of availability of this primary blood product, providing a strong rationale for developing recombinant alternatives. During the last decade, a tremendous number of novel insights into IVIg activity brought the goal of replacing IVIg within reach, at least in select indications, and has led to the initiation of several clinical trials. At the forefront of this effort is the modulation of autoantibody half-life and blocking access of autoantibodies to fragment cystallizable γ receptors (Fcγ receptors). In this rostrum article, we will briefly discuss current models of IVIg activity, followed by a more specific focus on novel therapeutic avenues that are entering the clinic and may replace IVIg in the future.
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Belgium (BE)How to cite
APA:
Shock, A., Humphreys, D., & Nimmerjahn, F. (2020). Dissecting the mechanism of action of intravenous immunoglobulin in human autoimmune disease: Lessons from therapeutic modalities targeting Fcγ receptors. Journal of Allergy and Clinical Immunology, 146(3), 492-500. https://doi.org/10.1016/j.jaci.2020.06.036
MLA:
Shock, Anthony, David Humphreys, and Falk Nimmerjahn. "Dissecting the mechanism of action of intravenous immunoglobulin in human autoimmune disease: Lessons from therapeutic modalities targeting Fcγ receptors." Journal of Allergy and Clinical Immunology 146.3 (2020): 492-500.
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