Mir-155-5p and mir-203a-3p are prognostic factors in soft tissue sarcoma

Greither T, Koser F, Holzhausen HJ, Güttler A, Würl P, Kappler M, Wach S, Taubert H (2020)

Publication Type: Journal article

Publication year: 2020

Journal

Cancers MDPI

Book Volume: 12

Pages Range: 1-13

Article Number: 2254

Journal Issue: 8

DOI: 10.3390/cancers12082254

Abstract

Soft tissue sarcoma (STS) is a heterogeneous group of rare malignancies with a five-year survival rate of approximately 50%. Reliable molecular markers for risk stratification and subsequent therapy management are still needed. Therefore, we analyzed the prognostic potential of miR-155-5p and miR-203a-3p expression in a cohort of 79 STS patients. MiR-155-5p and miR-203a-3p expression was measured from tumor total RNA by qPCR and correlated with the demographic, clinicopathological, and prognostic data of the patients. Elevated miR-155-5p expression was significantly associated with increased tumor stage and hypoxia-associated mRNA/protein expression. High miR-155-5p expression and low miR-203a-3p expression, as well as a combination of high miR-155-5p and low miR-203a-3p expression, were significantly associated with poor disease-specific survival in STS patients in the Kaplan–Meier survival analyses (p = 0.027, p = 0.001 and p = 0.0003, respectively) and in the univariate Cox regression analyses (RR = 1.96; p = 0.031; RR = 2.59; p = 0.002 and RR = 4.76; p = 0.001, respectively), but not in the multivariate Cox regression analyses. In conclusion, the oncomiR miR-155-5p and the tumor suppressor-miR miR-203a-3p exhibit an association with STS patient prognosis and are suggested as candidates for risk assessment.

Authors with CRIS profile

Helge Taubert Professur für Molekulare Urologie

Involved external institutions

Westfälische Wilhelms-Universität (WWU) Münster DE Germany (DE) Martin-Luther-Universität Halle-Wittenberg (MLU) DE Germany (DE) Städtisches Klinikum Dessau DE Germany (DE)

How to cite

APA:

Greither, T., Koser, F., Holzhausen, H.J., Güttler, A., Würl, P., Kappler, M.,... Taubert, H. (2020). Mir-155-5p and mir-203a-3p are prognostic factors in soft tissue sarcoma. Cancers, 12(8), 1-13. https://dx.doi.org/10.3390/cancers12082254

MLA:

Greither, Thomas, et al. "Mir-155-5p and mir-203a-3p are prognostic factors in soft tissue sarcoma." Cancers 12.8 (2020): 1-13.

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