Association between tissue hypoxia, perfusion restrictions, and microvascular architecture alterations with lesion-induced impairment of neurovascular coupling

Stadlbauer A, Kinfe TM, Zimmermann M, Eyüpoglu IY, Brandner N, Buchfelder M, Zaiß M, Dörfler A, Brandner S (2020)

Publication Type: Journal article

Publication year: 2020

Journal

Journal of Cerebral Blood Flow and Metabolism

DOI: 10.1177/0271678X20947546

Abstract

Functional magnetic resonance imaging (fMRI) has been mainly utilized for the preoperative localization of eloquent cortical areas. However, lesion-induced impairment of neurovascular coupling (NVC) in the lesion border zone may lead to false-negative fMRI results. The purpose of this study was to determine physiological factors impacting the NVC. Twenty patients suffering from brain lesions were preoperatively examined using multimodal neuroimaging including fMRI, magnetoencephalography (MEG) during language or sensorimotor tasks (depending on lesion location), and a novel physiologic MRI approach for the combined quantification of oxygen metabolism, perfusion state, and microvascular architecture. Congruence of brain activity patterns between fMRI and MEG were found in 13 patients. In contrast, we observed missing fMRI activity in perilesional cortex that demonstrated MEG activity in seven patients, which was interpreted as lesion-induced impairment of NVC. In these brain regions with impaired NVC, physiologic MRI revealed significant brain tissue hypoxia, as well as significantly decreased macro- and microvascular perfusion and microvascular architecture. We demonstrated that perilesional hypoxia with reduced vascular perfusion and architecture is associated with lesion-induced impairment of NVC. Our physiologic MRI approach is a clinically applicable method for preoperative risk assessment for the presence of false-negative fMRI results and may prevent severe postoperative functional deficits.

Authors with CRIS profile

Thomas Mehari Kinfe Professur für Neurochirurgie mit dem Schwerpunkt Funktionelle Stereotaktische Neurochirurgie Max Zimmermann Department of Neurosurgery Ilker Yasin Eyüpoglu Department of Neurosurgery Michael Buchfelder Lehrstuhl für Neurochirurgie Moritz Zaiß Professur für Multimodale Bildgebung in der klinischen Forschung Arnd Dörfler Department of Neuroradiology Sebastian Brandner Department of Neurosurgery

How to cite

APA:

Stadlbauer, A., Kinfe, T.M., Zimmermann, M., Eyüpoglu, I.Y., Brandner, N., Buchfelder, M.,... Brandner, S. (2020). Association between tissue hypoxia, perfusion restrictions, and microvascular architecture alterations with lesion-induced impairment of neurovascular coupling. Journal of Cerebral Blood Flow and Metabolism. https://doi.org/10.1177/0271678X20947546

MLA:

Stadlbauer, Andreas, et al. "Association between tissue hypoxia, perfusion restrictions, and microvascular architecture alterations with lesion-induced impairment of neurovascular coupling." Journal of Cerebral Blood Flow and Metabolism (2020).

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