The relationship between glial cell mechanosensitivity and foreign body reactions in the central nervous system
Moshayedi P, Ng G, Kwok JCF, Yeo GSH, Bryant CE, Fawcett JW, Franze K, Guck J (2014)
Publication Type: Journal article
Publication year: 2014
Journal
Book Volume: 35
Pages Range: 3919-3925
Journal Issue: 13
DOI: 10.1016/j.biomaterials.2014.01.038
Abstract
Devices implanted into the body become encapsulated due to a foreign body reaction. In the central nervous system (CNS), this can lead to loss of functionality in electrodes used to treat disorders. Around CNS implants, glial cells are activated, undergo gliosis and ultimately encapsulate the electrodes. The primary cause of this reaction is unknown. Here we show that the mechanical mismatch between nervous tissue and electrodes activates glial cells. Both primary rat microglial cells and astrocytes responded to increasing the contact stiffness from physiological values (. G'~100Pa) to shear moduli G'≥10kPa by changes in morphology and upregulation of inflammatory genes and proteins. Upon implantation of composite foreign bodies into rat brains, foreign body reactions were significantly enhanced around their stiff portions invivo. Our results indicate that CNS glial cells respond to mechanical cues, and suggest that adapting the surface stiffness of neural implants to that of nervous tissue could minimize adverse reactions and improve biocompatibility. © 2014 The Authors.
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United Kingdom (GB)How to cite
APA:
Moshayedi, P., Ng, G., Kwok, J.C.F., Yeo, G.S.H., Bryant, C.E., Fawcett, J.W.,... Guck, J. (2014). The relationship between glial cell mechanosensitivity and foreign body reactions in the central nervous system. Biomaterials, 35(13), 3919-3925. https://dx.doi.org/10.1016/j.biomaterials.2014.01.038
MLA:
Moshayedi, Pouria, et al. "The relationship between glial cell mechanosensitivity and foreign body reactions in the central nervous system." Biomaterials 35.13 (2014): 3919-3925.
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