ECM-Regulator timp Is Required for Stem Cell Niche Organization and Cyst Production in the Drosophila Ovary
Pearson JR, Zurita F, Tomas-Gallardo L, Diaz-Torres A, Del Carmen Diaz De La Loza M, Franze K, Martin-Bermudo MD, Gonzalez-Reyes A (2016)
Publication Type: Journal article
Publication year: 2016
Journal
Book Volume: 12
Article Number: e1005763
Journal Issue: 1
DOI: 10.1371/journal.pgen.1005763
Abstract
The extracellular matrix (ECM) is a pivotal component adult tissues and of many tissue-specific stem cell niches. It provides structural support and regulates niche signaling during tissue maintenance and regeneration. In many tissues, ECM remodeling depends on the regulation of MMP (matrix metalloproteinase) activity by inhibitory TIMP (tissue inhibitors of metalloproteinases) proteins. Here, we report that the only Drosophila timp gene is required for maintaining the normal organization and function of the germline stem cell niche in adult females. timp mutant ovaries show reduced levels of both Drosophila Collagen IV α chains. In addition, tissue stiffness and the cellular organization of the ovarian niche are affected in timp mutants. Finally, loss of timp impairs the ability of the germline stem cell niche to generate new cysts. Our results demonstrating a crucial role for timp in tissue organization and gamete production thus provide a link between the regulation of ECM metabolism and tissue homeostasis.
Authors with CRIS profile
Involved external institutions
Universidad Pablo de Olavide of Seville
Spain (ES)
University of Cambridge
United Kingdom (GB)
Universidad de Granada
Spain (ES)
Spain (ES)
University of Cambridge
United Kingdom (GB)
Universidad de Granada
Spain (ES)
How to cite
APA:
Pearson, J.R., Zurita, F., Tomas-Gallardo, L., Diaz-Torres, A., Del Carmen Diaz De La Loza, M., Franze, K.,... Gonzalez-Reyes, A. (2016). ECM-Regulator timp Is Required for Stem Cell Niche Organization and Cyst Production in the Drosophila Ovary. PLoS Genetics, 12(1). https://dx.doi.org/10.1371/journal.pgen.1005763
MLA:
Pearson, John R., et al. "ECM-Regulator timp Is Required for Stem Cell Niche Organization and Cyst Production in the Drosophila Ovary." PLoS Genetics 12.1 (2016).
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