4D Biofabrication of fibrous artificial nerve graft for neuron regeneration

Apsite I, Constante G, Dulle M, Vogt L, Caspari A, Boccaccini AR, Synytska A, Salehi S, Ionov L (2020)

Publication Type: Journal article

Publication year: 2020

Journal

Biofabrication IOP Publishing

Book Volume: 12

Article Number: 035027

Journal Issue: 3

DOI: 10.1088/1758-5090/ab94cf

Abstract

In this paper, we describe the application of the 4D biofabrication approach for the fabrication of artificial nerve graft. Bilayer scaffolds consisting of uniaxially aligned polycaprolactone-poly(glycerol sebacate) (PCL-PGS) and randomly aligned methacrylated hyaluronic acid (HA-MA) fibers were fabricated using electrospinning and further used for the culture of PC-12 neuron cells. Tubular structures form instantly after immersion of fibrous bilayer in an aqueous buffer and the diameter of obtained tubes can be controlled by changing bilayer parameters such as the thickness of each layer, overall bilayer thickness, and medium counterion concentration. Designed scaffolds showed a self-folded scroll-like structure with high stability after four weeks of real-time degradation. The significance of this research is in the fabrication of tuneable tubular nerve guide conduits that can simplify the current existing clinical treatment of neural injuries.

Authors with CRIS profile

Lena Vogt Lehrstuhl für Werkstoffwissenschaften (Biomaterialien) Aldo Boccaccini Lehrstuhl für Werkstoffwissenschaften (Biomaterialien)

Involved external institutions

Universität Bayreuth DE Germany (DE) Forschungszentrum Jülich / Research Centre Jülich (FZJ) DE Germany (DE) Leibniz-Institut für Polymerforschung Dresden e. V. DE Germany (DE)

How to cite

APA:

Apsite, I., Constante, G., Dulle, M., Vogt, L., Caspari, A., Boccaccini, A.R.,... Ionov, L. (2020). 4D Biofabrication of fibrous artificial nerve graft for neuron regeneration. Biofabrication, 12(3). https://dx.doi.org/10.1088/1758-5090/ab94cf

MLA:

Apsite, Indra, et al. "4D Biofabrication of fibrous artificial nerve graft for neuron regeneration." Biofabrication 12.3 (2020).

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