Thirty Mouse Strain Survey of Voluntary Physical Activity and Energy Expenditure: Influence of Strain, Sex and Day–Night Variation

König C, Plank AC, Kapp A, Timotius I, von Hörsten S, Zimmermann K (2020)

Publication Type: Journal article

Publication year: 2020

Journal

Frontiers in Neuroscience Frontiers Research Foundation / Frontiers Media

Book Volume: 14

Article Number: 531

DOI: 10.3389/fnins.2020.00531

Abstract

We measured indirect calorimetry and activity parameters, VO2 and VCO2 to extract respiratory exchange ratio (RER) and energy expenditure in both sexes of 30 inbred mouse strains of 6 genetic families at 9–13 weeks during one photophase and the subsequent scotophase. We observed a continuous distribution of all traits. While males had higher body weights than females, we observed no sex difference for food and water intake. All strains drank and fed more during the night even if they displayed no day–night difference in activity traits. Several strains showed absent or weak day–night variation in one or more activity traits and these included FVB and 129X1, males of 129S1, SWR, NZW, and SM, and females of SJL. In general females showed higher rearing and ambulatory activity with 6 and 9 strains, respectively, showing a sex difference. Fine motor movements, like grooming, showed less sex differences. RER underlied a strong day–night difference and no sex effect. Only FVB females and males of the RIIIS and SM strain had no day–night variation. Energy expenditure underlies a large day–night variation which was absent in SWR and in FVB females and RIIIS males. In general, female bodies had a tendency to higher energy expenditure values, which became a significant difference in C3H, MAMy, SM, DBA1, and BUB. Our data illustrate the diversity of these traits in male and female inbred mice and provide a resource in the selection of strains for future studies.

Authors with CRIS profile

Christine König Department of Anaesthesiology Anne-Christine Plank Professur für Experimentelle Biomedizin Alexander Kapp Heisenbergprofessur für Experimentelle Schmerzforschung Ivanna Timotius Lehrstuhl für Informatik 14 (Machine Learning and Data Analytics) Stephan von Hörsten Professur für Experimentelle Biomedizin Katharina Zimmermann Heisenbergprofessur für Experimentelle Schmerzforschung

Additional Organisation(s)

Machine Learning and Data Analytics Lab

How to cite

APA:

König, C., Plank, A.-C., Kapp, A., Timotius, I., von Hörsten, S., & Zimmermann, K. (2020). Thirty Mouse Strain Survey of Voluntary Physical Activity and Energy Expenditure: Influence of Strain, Sex and Day–Night Variation. Frontiers in Neuroscience, 14. https://dx.doi.org/10.3389/fnins.2020.00531

MLA:

König, Christine, et al. "Thirty Mouse Strain Survey of Voluntary Physical Activity and Energy Expenditure: Influence of Strain, Sex and Day–Night Variation." Frontiers in Neuroscience 14 (2020).

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