Endometrial Dating Method Detects Individual Maturation Sequences During the Secretory Phase

Alfer J, Fattahi A, Bleisinger N, Krieg J, Behrens R, Dittrich R, Beckmann M, Hartmann A, Classen-Linke I, Popovici RM (2020)

Publication Type: Journal article

Publication year: 2020

Journal

In Vivo International Institute of Anticancer Research (IIAR)

Book Volume: 34

Pages Range: 1951-1963

Journal Issue: 4

DOI: 10.21873/invivo.11992

Abstract

BACKGROUND/AIM: This study assessed whether a new immunohistochemical dating method allows precise endometrial dating allowing optimal timing for embryo transfer. PATIENTS AND METHODS: A novel method was used for endometrial dating, with parameters including menstrual cycle days, Noyes histological criteria, along with immunohistochemical expression pattern of estrogen and progesterone receptors and proliferation marker Ki-67. Endometrial maturation was analyzed on days +5 to +10 after ovulation or progesterone administration in 217 biopsies from 151 subfertile patients during the secretory phase. RESULTS: Endometrial maturation varied individually, occurring 1.68±1.67 days late. Comparison of histological maturation with clinical days after ovulation showed a delay of about 2 days. CONCLUSION: Endometrial maturation requires 8 days, rather than the expected 6 days, to reach the histological mid-secretory phase. This is not a delay and is also seen in fertile patients. The new analysis method used is superior to that using Noyes criteria alone and provides a better basis for determining conditions for optimal timing of embryo transfers.

Authors with CRIS profile

Nathalie Bleisinger Professur für Experimentelle Reproduktionsmedizin Ralf Dittrich Professur für Experimentelle Reproduktionsmedizin Matthias Beckmann Lehrstuhl für Geburtshilfe und Frauenheilkunde Arndt Hartmann Lehrstuhl für Allgemeine Pathologie und Pathologische Anatomie

Involved external institutions

Rheinisch-Westfälische Technische Hochschule (RWTH) Aachen DE Germany (DE)

How to cite

APA:

Alfer, J., Fattahi, A., Bleisinger, N., Krieg, J., Behrens, R., Dittrich, R.,... Popovici, R.M. (2020). Endometrial Dating Method Detects Individual Maturation Sequences During the Secretory Phase. In Vivo, 34(4), 1951-1963. https://dx.doi.org/10.21873/invivo.11992

MLA:

Alfer, Joachim, et al. "Endometrial Dating Method Detects Individual Maturation Sequences During the Secretory Phase." In Vivo 34.4 (2020): 1951-1963.

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