Incisionless MR-guided focused ultrasound: technical considerations and current therapeutic approaches in psychiatric disorders
Kinfe TM, Stadlbauer A, Winder K, Hurlemann R, Buchfelder M (2020)
Publication Type: Journal article, Review article
Publication year: 2020
Journal
DOI: 10.1080/14737175.2020.1779590
Abstract
Introduction: MR-guided focused ultrasound operating at higher intensities have been reported to effectively and precisely ablate deeper brain structures like the basal ganglia or the thalamic nuclei for the treatment of refractory movement disorders, neuropathic pain and most recently neuropsychiatric disorders, while low-intensity focused ultrasound represents an approach promoting mechanical blood-brain-barrier opening and neuromodulation. This narrative review summarizes the technical development and the therapeutic potential of incisionless MRgFUS in order to treat neuropsychiatric disorders. Areas covered: A narrative review of clinical trials assessing the safety and efficacy of MRgFUS. A literature review was performed using the following search terms: MR-guided focused ultrasound, psychiatric disorders, noninvasive and invasive brain modulation/stimulation techniques. Expert opinion: MRgFUS ablation is under clinical investigation (unblinded study design) for obsessive-compulsive disorders (OCDs) [capsulotomy; ALIC] and depression/anxiety disorders [capsulotomy] and has demonstrated an improvement in OCD and depression, although of preliminary character. Low-intensity ultrasound applications have been explored in Alzheimer´s disease (phase 1 study) and healthy subjects. Currently, limited evidence hinders comparison and selection between MRgFUS and noninvasive/invasive brain modulation therapies. However, comparative, sham-controlled trials are needed to reexamine the preliminary findings for the treatment of psychiatric disorders.
Authors with CRIS profile
Thomas Mehari Kinfe
Professur für Neurochirurgie mit dem Schwerpunkt Funktionelle Stereotaktische Neurochirurgie
Michael Buchfelder
Lehrstuhl für Neurochirurgie
Involved external institutions
Germany (DE)How to cite
APA:
Kinfe, T.M., Stadlbauer, A., Winder, K., Hurlemann, R., & Buchfelder, M. (2020). Incisionless MR-guided focused ultrasound: technical considerations and current therapeutic approaches in psychiatric disorders. Expert review of neurotherapeutics. https://dx.doi.org/10.1080/14737175.2020.1779590
MLA:
Kinfe, Thomas Mehari, et al. "Incisionless MR-guided focused ultrasound: technical considerations and current therapeutic approaches in psychiatric disorders." Expert review of neurotherapeutics (2020).
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