A Mathematical Model of HIF-1 Regulated Cellular Energy Metabolism
Bocharov G, Jäger W, Knoch J, Neuss-Radu M, Thiel M (2020)
Publication Language: English
Publication Type: Journal article
Publication year: 2020
Journal
DOI: 10.1007/s10013-020-00426-y
Open Access Link: https://link.springer.com/content/pdf/10.1007/s10013-020-00426-y.pdf
Abstract
In this study, we formulated a mathematical model of hypoxia-inducible factor 1 (HIF-1)mediated regulation of cellular energy metabolism describing the reprogramming of cellmetabolic processes from oxidative phosphorylation to glycolysis under reduced oxygenlevels. The model considers the dynamics of fifteen biochemical species and the protonconcentration with the underlying reaction processes localized in three intracellular com-partments, i.e. the cytoplasm, mitochondrion and nucleus. More than sixty parameters ofthe model were calibrated using both the published data and the system steady-state basedidentification procedure. The model was validated by generating predictions which could becompared to empirical observations. The model behaviors representing the cell metabolismswitching over in response to transitioning from a normoxic to hypoxic environment areconsistent with the current views of the role of HIF-1 in hypoxia.
Authors with CRIS profile
Jonas Knoch
Naturwissenschaftliche Fakultät
Maria Neuß
Lehrstuhl für Angewandte Mathematik (Modellierung und Numerik)
Involved external institutions
Ruprecht-Karls-Universität Heidelberg
Germany (DE)
Universitätsklinikum Mannheim
Germany (DE)
Russian Academy of Sciences / Росси́йская акаде́мия нау́к (RAS)
Russian Federation (RU)
Germany (DE)
Universitätsklinikum Mannheim
Germany (DE)
Russian Academy of Sciences / Росси́йская акаде́мия нау́к (RAS)
Russian Federation (RU)
How to cite
APA:
Bocharov, G., Jäger, W., Knoch, J., Neuss-Radu, M., & Thiel, M. (2020). A Mathematical Model of HIF-1 Regulated Cellular Energy Metabolism. Vietnam Journal of Mathematics. https://dx.doi.org/10.1007/s10013-020-00426-y
MLA:
Bocharov, Gennady, et al. "A Mathematical Model of HIF-1 Regulated Cellular Energy Metabolism." Vietnam Journal of Mathematics (2020).
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