Role of shear and extensional stress on the degradation of proteins during downstream processing

Simon S, Weber C, Peukert W (2010)


Publication Language: English

Publication Status: Published

Publication Type: Conference contribution, Conference Contribution

Publication year: 2010

Event location: Salt Lake City, UT US

ISBN: 9780816910656

URI: https://www.scopus.com/record/display.uri?eid=2-s2.0-78751508585&origin=inward

Abstract

In most applications of biotechnology and downstream processing proteins are stressed in various flow configurations by shear and extensional stress. In this work we present stress experiments of several proteins under well-defined flow conditions. In combination with insitu analytics flow-induced aggregation phenomena and conformational changes can be successfully monitored. In addition to shear and elongation, the contribution of adsorption phenomena to interfaces is investigated.

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How to cite

APA:

Simon, S., Weber, C., & Peukert, W. (2010). Role of shear and extensional stress on the degradation of proteins during downstream processing. In Proceedings of the 2010 AIChE Annual Meeting, 10AIChE. Salt Lake City, UT, US.

MLA:

Simon, Sonja, Carsten Weber, and Wolfgang Peukert. "Role of shear and extensional stress on the degradation of proteins during downstream processing." Proceedings of the 2010 AIChE Annual Meeting, 10AIChE, Salt Lake City, UT 2010.

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