Sodium relaxometry using 23 Na MR fingerprinting: A proof of concept

Kratzer FJ, Flassbeck S, Nagel AM, Behl NG, Knowles BR, Bachert P, Ladd ME, Schmitter S (2020)

Publication Type: Journal article

Publication year: 2020

Journal

Magnetic Resonance in Medicine Wiley

DOI: 10.1002/mrm.28316

Abstract

PURPOSE: To evaluate the feasibility of 23 Na MR fingerprinting (MRF) for simultaneous quantification of T1 , formula presented , formula presented in addition to ΔB0 . METHODS: A framework for sodium relaxometry using MRF at 7T was developed, allowing simultaneous measurement of relaxation times and inhomogeneities in the static field. The technique distinguishes between bi- and monoexponential transverse relaxation and was validated in simulations with respect to the ground truth. In phantom measurements, a resolution of 2 × 2 × 12 mm3 was achieved within 1 h acquisition time, and the resulting parameter maps were compared to results from reference methods. Relaxation times in five healthy volunteers were measured with a resolution of 4 × 4 × 12 mm3 . RESULTS: Phantom experiments revealed an agreement between the relaxation times obtained via 23 Na-MRF and the reference methods. In white matter, a longitudinal relaxation constant of T1 = 38.9 ± 4.8 ms was found, while values of formula presented = 29.2 ± 4.9 ms and formula presented = 4.7 ± 1.2 ms were found for the long and short component of the transverse relaxation. In cerebrospinal fluid, T1 was 67.7 ± 6.3 ms and formula presented = 41.5 ± 3.4 ms. CONCLUSION: This work demonstrates the feasibility of 23 Na-MRF for relaxometry in sodium MRI in both phantom and in vivo studies. Simultaneous quantification of T1 , formula presented , formula presented and ΔB0 was possible within a 1 h measurement time.

Authors with CRIS profile

Armin Michael Nagel Professur für metabolische und funktionelle MR-Bildgebung

Involved external institutions

Deutsches Krebsforschungszentrum (DKFZ) DE Germany (DE)

How to cite

APA:

Kratzer, F.J., Flassbeck, S., Nagel, A.M., Behl, N.G., Knowles, B.R., Bachert, P.,... Schmitter, S. (2020). Sodium relaxometry using 23 Na MR fingerprinting: A proof of concept. Magnetic Resonance in Medicine. https://dx.doi.org/10.1002/mrm.28316

MLA:

Kratzer, Fabian J., et al. "Sodium relaxometry using 23 Na MR fingerprinting: A proof of concept." Magnetic Resonance in Medicine (2020).

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