Individual Calculation of Effective Dose and Risk of Malignancy Based on Monte Carlo Simulations after Whole Body Computed Tomography

Kopp M, Loewe T, Wüst W, Brand M, Wetzl M, Nitsch W, Schmidt D, Beck M, Schmidt B, Uder M, May M (2020)

Publication Type: Journal article

Publication year: 2020

Journal

Scientific Reports Nature Publishing Group: Open Access Journals - Option B

Book Volume: 10

Article Number: 9475

Journal Issue: 1

DOI: 10.1038/s41598-020-66366-2

Abstract

Detailed knowledge about radiation exposure is crucial for radiology professionals. The conventional calculation of effective dose (ED) for computed tomography (CT) is based on dose length product (DLP) and population-based conversion factors (k). This is often imprecise and unable to consider individual patient characteristics. We sought to provide more precise and individual radiation exposure calculation using image based Monte Carlo simulations (MC) in a heterogeneous patient collective and to compare it to phantom based MC provided from the National Cancer Institute (NCI) as academic reference. Dose distributions were simulated for 22 patients after whole-body CT during Positron Emission Tomography-CT. Based on MC we calculated individual Lifetime Attributable Risk (LAR) and Excess Relative Risk (ERR) of cancer mortality. EDMC was compared to EDDLP and EDNCI. EDDLP (13.2 ± 4.5 mSv) was higher compared to EDNCI (9.8 ± 2.1 mSv) and EDMC (11.6 ± 1.5 mSv). Relative individual differences were up to −48% for EDMC and −44% for EDNCI compared to EDDLP. Matching pair analysis illustrates that young age and gender are affecting LAR and ERR significantly. Because of these uncertainties in radiation dose assessment automated individual dose and risk estimation would be desirable for dose monitoring in the future.

Authors with CRIS profile

Markus Kopp Medizinische Fakultät Wolfgang Wüst Medizinische Fakultät Michael Brand Lehrstuhl für Diagnostische Radiologie Matthias Wetzl Institute of Radiology Daniela Schmidt Medizinische Fakultät Michael Beck Lehrstuhl für Klinische Nuklearmedizin Michael Uder Lehrstuhl für Diagnostische Radiologie Matthias May Institute of Radiology

Involved external institutions

Technische Universität Dresden DE Germany (DE)

How to cite

APA:

Kopp, M., Loewe, T., Wüst, W., Brand, M., Wetzl, M., Nitsch, W.,... May, M. (2020). Individual Calculation of Effective Dose and Risk of Malignancy Based on Monte Carlo Simulations after Whole Body Computed Tomography. Scientific Reports, 10(1). https://doi.org/10.1038/s41598-020-66366-2

MLA:

Kopp, Markus, et al. "Individual Calculation of Effective Dose and Risk of Malignancy Based on Monte Carlo Simulations after Whole Body Computed Tomography." Scientific Reports 10.1 (2020).

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