Phylogenomic characterisation of a novel corynebacterial species pathogenic to animals

Möller J, Musella L, Melnikov V, Geißdörfer W, Burkovski A, Sangal V (2020)

Publication Type: Journal article

Publication year: 2020

Journal

Antonie Van Leeuwenhoek International Journal of General and Molecular Microbiology Springer Verlag (Germany)

DOI: 10.1007/s10482-020-01430-5

Abstract

The genus Corynebacterium includes species of biotechnological, medical and veterinary importance. An atypical C. ulcerans strain, W25, was recently isolated from a case of necrotizing lymphadenitis in a wild boar. In this study, we have analysed the genome sequence of this strain and compared the phenotypic and virulence properties with other corynebacterial pathogens. Phylogenomic analyses revealed that strain W25 belongs to a novel species along with PO100/5 and KL1196. The latter strains were isolated from a pig and a roe deer, respectively; hence, this species appears to be associated to animals. The isolate W25 is likely a non-toxigenic tox gene bearing strain and may have compromised abilities to adhere to pharyngeal and laryngeal epithelial cells due to potential loss of the gene functions in spaBC and spaDEF pilus gene clusters. A number of corynebacterial virulence genes are present including pld encoding phospholipase D. Therefore, this strain may be able to cause severe invasive infections in animals and zoonotic infections in humans.

Authors with CRIS profile

Jens Möller Professur für Mikrobiologie Andreas Burkovski Professur für Mikrobiologie

Involved external institutions

Northumbria University GB United Kingdom (GB) Gabrichevsky Institute of Epidemiology and Microbiology DE Germany (DE)

How to cite

APA:

Möller, J., Musella, L., Melnikov, V., Geißdörfer, W., Burkovski, A., & Sangal, V. (2020). Phylogenomic characterisation of a novel corynebacterial species pathogenic to animals. Antonie Van Leeuwenhoek International Journal of General and Molecular Microbiology. https://dx.doi.org/10.1007/s10482-020-01430-5

MLA:

Möller, Jens, et al. "Phylogenomic characterisation of a novel corynebacterial species pathogenic to animals." Antonie Van Leeuwenhoek International Journal of General and Molecular Microbiology (2020).

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