Bone Mass, Bone Microstructure and Biomechanics in Patients with Hand Osteoarthritis

Simon D, Tascilar K, Unbehend S, Bayat S, Berlin A, Liphardt AM, Meinderink T, Rech J, Hueber A, Schett G, Kleyer A (2020)

Publication Type: Journal article

Publication year: 2020

Journal

Journal of Bone and Mineral Research American Society for Bone and Mineral Research

DOI: 10.1002/jbmr.4046

Abstract

The impact of primary hand osteoarthritis (HOA) on bone mass, microstructure, and biomechanics in the affected skeletal regions is largely unknown. HOA patients and healthy controls (HCs) underwent high-resolution peripheral quantitative computed tomography (HR-pQCT). We measured total, trabecular, and cortical volumetric bone mineral densities (vBMDs), microstructural attributes, and performed micro–finite element analysis for bone strength. Failure load and scaled multivariate outcome matrices from distal radius and second metacarpal (MCP2) head measurements were analyzed using multiple linear regression adjusting for age, sex, and functional status and reported as adjusted Z-score differences for total and direct effects. A total of 105 subjects were included (76 HC: 46 women, 30 men; 29 HOA: 23 women, six men). After adjustment, HOA was associated with significant changes in the multivariate outcome matrix from the MCP2 head (p <.001) (explained by an increase in cortical vBMD (Δz = 1.07, p =.02) and reduction in the trabecular vBMD (Δz = −0.07, p =.09). Distal radius analysis did not show an overall effect of HOA; however, there was a gender-study group interaction (p =.044) explained by reduced trabecular vBMD in males (Δz = −1.23, p =.02). HOA was associated with lower failure load (−514 N; 95%CI, −1018 to −9; p = 0.05) apparent in males after adjustment for functional status. HOA is associated with reduced trabecular and increased cortical vBMD in the MCP2 head and a reduction in radial trabecular vBMD and bone strength in males. Further investigations of gender-specific changes of bone architecture in HOA are warranted. © 2020 The Authors. Journal of Bone and Mineral Research published by American Society for Bone and Mineral Research.

Authors with CRIS profile

David Simon Department of Medicine 3 – Rheumatology and Immunology Sara Unbehend Medizinische Fakultät Sara Bayat Lehrstuhl für Innere Medizin III Andreas Berlin Lehrstuhl für Innere Medizin III Anna-Maria Liphardt Department of Medicine 3 – Rheumatology and Immunology Timo Meinderink Department of Medicine 3 – Rheumatology and Immunology Hans Jürgen Rech Department of Medicine 3 – Rheumatology and Immunology Axel Hueber Department of Medicine 3 – Rheumatology and Immunology Georg Schett Lehrstuhl für Innere Medizin III Arnd Kleyer Department of Medicine 3 – Rheumatology and Immunology

How to cite

APA:

Simon, D., Tascilar, K., Unbehend, S., Bayat, S., Berlin, A., Liphardt, A.-M.,... Kleyer, A. (2020). Bone Mass, Bone Microstructure and Biomechanics in Patients with Hand Osteoarthritis. Journal of Bone and Mineral Research. https://doi.org/10.1002/jbmr.4046

MLA:

Simon, David, et al. "Bone Mass, Bone Microstructure and Biomechanics in Patients with Hand Osteoarthritis." Journal of Bone and Mineral Research (2020).

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